Medication Causes of Pericarditis

Aka: Medication Causes of Pericarditis, Pericarditis due to Medications, Drug-Induced Pericarditis

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II. Causes: Antibiotics

  1. Isoniazid
  2. Penicillins
  3. Rifampin
  4. Streptomycin
  5. Sulfonamides

III. Causes: Chemotherapy

  1. Anthracycline Antibiotic (Daunorubicin, Doxorubicin)
  2. Cyclophosphamide
  3. Cytarabine
  4. Fluorouracil

IV. Causes: Cardiovascular

  1. Hydralazine (Drug-induced Lupus)
  2. Methyldopa
  3. Procainamide (Drug-induced Lupus)
  4. Thiazide Diuretics

V. Causes: Rheumatologic

  1. Agents associated with Lupus-Like Syndrome (Pericarditis is a serositis)
    1. See Drug-induced Lupus
    2. Hydralazine is the most common cause
    3. Other causes include Procainamide, Isoniazid, Minocycline, Terbinafine, Phenytoin
  2. Other rheumatologic agents and Immunosuppressants
    1. Cyclosporine
    2. TNF Inhibitor

VI. Causes: Neuropsychiatric

  1. Bromocriptine
  2. Clozapine
  3. Dantrolene
  4. Methylsergide
  5. Phenytoin (Drug-induced Lupus)

VII. Causes: Miscellaneous

  1. Mesalamine
  2. Granulocyte-Macrophage Colony Stimulating Factor
  3. Thiouracils
  4. SARS-CoV-2 Vaccine
    1. Pericarditis or Myocarditis was associated with BNT162b2 and mRNA-1273 Vaccines
    2. Incidence has been low (<2 per 100,000), even in the highest risk groups (young males age 18 to 25 years)
    3. lane (2022) bmj open 12(5): e059223 [PubMed]
    4. wong (2022) lancet 399(10342): 2191-9 [PubMed]
    5. abraham (2022) Vaccine 40(32): 4663-71 [PubMed]

VIII. References

  1. Peterson (2024) Am Fam Physician 109(5): 441-6 [PubMed]

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