III. Contraindications

  1. Chronic Kidney Disease Stage 4 (GFR <30 ml/min)
  2. Severe liver disease (Child-Pugh Score 10 or more)

IV. Dosing

  1. Take 8 mg daily with food
  2. Limit dose to 4 mg daily if GFR 30-50 ml/min

V. Adverse Effects

  1. See Selective Alpha-1a Antagonist
  2. Postural Hypotension (esp. when combined with Antihypertensives)
  3. Floppy Iris Syndrome
  4. Ejaculatory Dysfunction (class effect)

VI. Drug Interactions

  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  2. Avoid Silodosin with strong P-Glycoprotein Inhibitors

VIII. References

  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/

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Related Studies

Cost: Medications

silodosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SILODOSIN 4 MG CAPSULE Generic $0.45 each
SILODOSIN 8 MG CAPSULE Generic $0.63 each