II. Indications
III. Contraindications
- Chronic Kidney Disease Stage 4 (GFR <30 ml/min)
- Severe liver disease (Child-Pugh Score 10 or more)
IV. Dosing
- Take 8 mg daily with food
- Limit dose to 4 mg daily if GFR 30-50 ml/min
V. Adverse Effects
- See Selective Alpha-1a Antagonist
- Postural Hypotension (esp. when combined with Antihypertensives)
- Floppy Iris Syndrome
- Ejaculatory Dysfunction (class effect)
VI. Drug Interactions
- Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
- Avoid Silodosin with strong P-Glycoprotein Inhibitors
VII. Resources
VIII. References
- Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
- Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
Images: Related links to external sites (from Bing)
Related Studies
silodosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
SILODOSIN 4 MG CAPSULE | Generic | $0.45 each |
SILODOSIN 8 MG CAPSULE | Generic | $0.63 each |
Ontology: silodosin (C1870115)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C095285 |
SnomedCT | 441605002, 442042006 |
English | Silodosin, Silodosin (product), Silodosin (substance), SILODOSIN, silodosin (medication), silodosin, 1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethylamino)propyl)indoline-7-carboxamide |
Spanish | silodosina, silodosina (producto), silodosina (sustancia) |