II. Causes: Cardiovascular

  1. Antiarrhythmics
    1. See Sodium Channel Blockade Antiarrhythmics
    2. Class Ia: Lengthens Action Potential duration
      1. Quinidine
      2. Procainamide (Pronestyl)
      3. Disopyramide (Norpace)
      4. Amiodarone (also Class II, III, IV)
      5. Ajmaline (used to diagnostically provoke Arrhythmia in suspected Brugada Syndrome)
    3. Class Ib: Shortens Action Potential duration
      1. Lidocaine (Xylocaine)
      2. Tocainide (Tonocard)
      3. Mexiletine (Mexitil)
      4. Aprindine
    4. Class Ic: Slows conduction
      1. Flecainide (Tambocor)
      2. Encainide (Enkaid)
      3. Propafenone (Rythmol)
      4. Moracizine (Ethmozine, off U.S. market in 2007)
  2. Diuretic
    1. Triamterene
    2. Amiloride
  3. Beta-Blockers (esp. non-selective)
    1. Acebutolol
    2. Oxprenolol
    3. Propranolol

V. Causes: Miscellaneous

VI. Resources

  1. Sodium Channel Blocker Toxicity (Internet Book of Critical Care)
    1. https://emcrit.org/ibcc/nacb/

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Related Studies

Ontology: Sodium Channel Blockers (C0872271)

Definition (MSH) A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Concepts Pharmacologic Substance (T121)
MSH D026941
Swedish Natriumkanalblockerare
English NA CHANNEL BLOCK, CHANNEL BLOCK NA, Sodium Channel Blockers, sodium channel blockers, sodium channel blocker, Channel Blockers, Sodium, Channel Inhibitors, Sodium, Sodium Channel Inhibitors, Inhibitors, Sodium Channel
Czech sodíkové kanály - blokátory, inhibitory sodíkových kanálů
Finnish Natriumkanavansalpaajat
Russian KANALOV NATRIEVYKH BLOKATORY, NATRIEVYKH KANALOV BLOKATORY, ИНГИБИТОРЫ НАТРИЕВЫХ КАНАЛОВ, INGIBITORY NATRIEVYKH KANALOV, КАНАЛОВ НАТРИЕВЫХ БЛОКАТОРЫ, НАТРИЕВЫХ КАНАЛОВ БЛОКАТОРЫ
Japanese ナトリウムチャンネル遮断剤, Na+チャンネル遮断剤, ナトリウムチャンネル遮断薬, ナトリウムチャネル遮断薬, Na+チャンネル遮断薬, Naチャネルブロッカー, Naチャネル遮断薬, Naチャンネル遮断剤, Naチャンネル遮断薬, Naチャンネル阻害薬, チャンネル遮断剤-ナトリウム, ナトリウムチャネルブロッカー, 遮断剤-ナトリウムチャンネル
Spanish Bloqueantes de los Canales de Sodio, Bloqueadores de los Canales de Sodio
Polish Blokery kanałów sodowych
French Bloqueurs de canaux sodium, Inhibiteurs de canaux sodiques, Bloqueurs de canaux sodiques, Bloqueurs de canal sodique, Inhibiteurs de canaux sodium
Italian Bloccanti dei canali del sodio, Inibitori dei canali del sodio
German Kanalblocker, Natrium-, Natriumkanal-Blocker
Portuguese Bloqueadores dos Canais de Sódio