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Ontology:
topiramate
(C0076829)
Definition (CHV)
|
a kind of anticonvulsant drug
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Definition (NCI)
|
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C052342
|
SnomedCT |
108400009, 386844006 |
LNC |
LP19239-0, MTHU007741 |
English |
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate, topiramate, beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate, topiramate (medication), TOPIRAMATE, topiramate [Chemical/Ingredient], Topiramate, Topiramate (product), Topiramate (substance) |
Spanish |
topiramato (producto), topiramato (sustancia), topiramato |
Ontology:
Topamax
(C0723778)
Definition (CHV)
|
a migraine treatment medication
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C052342
|
English |
Topamax, topiramate (Topamax), Cilag brand of topiramate, Epitomax, Janssen brand of topiramate, Ortho brand of topiramate |