III. Adverse Effects: Dose related

  1. Interferes with concentration and memory
    1. Refered to pejoratively by some as "Dopamax"
  2. Confusion
  3. Sedation
  4. Lethargy
  5. Dizziness
  6. Ataxia
  7. Diplopia
  8. Tremor
  9. Nervousness
  10. Fatigue
  11. Depression
  12. Anorexia
  13. Dyspepsia

IV. Adverse Effects: Other

V. Drug Interactions

  1. Other Seizure medications

VI. Dose: Adult

  1. Initial: 25-50 mg/day (consider start just qhs)
  2. Increase by 25-50 mg/day increments per week
  3. Target
    1. Adults: 400 mg/day divided bid
    2. Elderly: 200 mg/day divided bid
  4. Maximum dose: 1600 mg/day divided bid

VII. Dose: Child

  1. Initial: 1-3 mg/kg up to 25 mg PO qhs for 1 week
  2. Increase by 1-3 mg/kg/day to 25 mg increments per week
  3. Target range: 5-9 mg/kg/day divided bid

VIII. Precautions

  1. Adjust dose if Creatinine Clearance <60 ml/min/sec

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Related Studies

Cost: Medications

topiramate (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TOPIRAMATE 100 MG TABLET Generic $0.06 each
TOPIRAMATE 15 MG SPRINKLE CAP Generic $0.60 each
TOPIRAMATE 200 MG TABLET Generic $0.10 each
TOPIRAMATE 25 MG SPRINKLE CAP Generic $0.69 each
TOPIRAMATE 25 MG TABLET Generic $0.04 each
TOPIRAMATE 50 MG TABLET Generic $0.04 each
TOPIRAMATE ER 100 MG CAPSULE Generic $15.46 each
TOPIRAMATE ER 150 MG CAPSULE Generic $16.07 each
TOPIRAMATE ER 200 MG CAPSULE Generic $19.28 each
TOPIRAMATE ER 25 MG CAPSULE Generic $5.20 each
TOPIRAMATE ER 50 MG CAPSULE Generic $6.65 each
topamax (on 6/22/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TOPAMAX 100 MG TABLET Generic $0.06 each
TOPAMAX 200 MG TABLET Generic $0.10 each
TOPAMAX 25 MG TABLET Generic $0.04 each
TOPAMAX 50 MG TABLET Generic $0.04 each