II. History
- Seen in epidemic form since the Middle Ages
- Implicated in alleged behavior of Salem witches
III. Causes
- Excessive Ergot alkaloid drug intake
- Ergot alkaloid used concurrently with potentiator
- Rye or wheat infected with fungus Claviceps purpurea
V. Signs: Gangrene of poorly vascularized distal structures
- Tip of nose
- Ears
- Fingers
- Toes