II. Indications
- Refractory partial-onset Seizures
III. Mechanism
- Antiepileptic
-
Glutamate receptor Antagonist (first in the class)
- Selective for AMPA receptors
IV. Precautions
- FDA Schedule III
- Abuse potential due to associated euphoria
V. Adverse Effects
- Mood changes
- Euphoria
- Anger
- Hostility
- Dizziness
- Sedation
VI. Dosing
- FDA approved for age over 12 years
- Initial: 2 mg orally at bedtime
- Titrate To: 4-8 mg orally at bedtime (increase by 2 mg/day on a weekly basis)
- Maximum: 12 mg/day
VII. Drug Interactions
-
Levonorgestrel containing contraceptives
- Perampanel decreases the contraceptive efficacy
- Use alternative agents
VIII. Resources
IX. References
- (2014) Presc Lett 21(11): 65
- French (2012) Neurology 79(6):589-96 [PubMed]
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