II. Mechanism

III. Indications

  1. Sjogren's Syndrome Dry Eyes (and possibly Dry Mouth) refractory to general measures

IV. Contraindications

  1. Angle closure Glaucoma
  2. Uncontrolled Asthma

V. Adverse effects

  1. Diaphoresis
  2. Decreased night Vision
  3. Nonselective agents (Pilocarpine) may have cardiopulmonary effects

VI. Medications

  1. Pilocarpine (Salagen)
    1. Nonselective (may have cardiac or lung effects)
    2. Dose: 5 mg orally twice daily
  2. Cevimeline (Evoxac)
    1. Selective for exocrine glands
    2. Dose: 30 mg orally three times daily

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Cost: Medications

pilocarpine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PILOCARPINE 1% EYE DROPS Generic $3.88 per ml
PILOCARPINE 2% EYE DROPS Generic $3.55 per ml
PILOCARPINE 4% EYE DROPS Generic $3.54 per ml
PILOCARPINE HCL 5 MG TABLET Generic $0.25 each
PILOCARPINE HCL 7.5 MG TABLET Generic $0.62 each
cevimeline (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CEVIMELINE HCL 30 MG CAPSULE Generic $1.11 each