II. Definitions
- Cholinomimetic Alkaloids
- Plant extracts with similar activity as Choline esters (e.g. Acetylcholine), but not susceptible to Cholinesterases
- Other than Nicotine (which acts at Nicotinic Receptors), most are Muscarinic Agonists
III. Adverse Effects
- See Cholinergic Toxicity (e.g. Organophosphate, Nerve Agent)
IV. Mechanism: Images
V. Medications: Choline Derivatives
- Background
- Primarily Muscarinic ReceptorAgonists (M1, M2, M3), with weak nicotinic activity (see Cholinergic Activity)
- Carbachol (Isopto Carbachol)
- Methacholine (Provocholine)
- Used in the Inhalation Challenge Test in the evaluation of Suspected allergen or Exercise-Induced Asthma
- Administered during Pulmonary Function Test to trigger bronchoconstriction in susceptible patients
- Susceptible to Cholinesterase metabolism, with a short Half-Life
- Bethanechol (Urecholine)
VI. Medications: Alkaloids
- Nicotinic Agonists
-
Muscarinic Agonists (M1, M2, M3)
- Cevimeline
- Used to treat Xerostomia in Sjogren Syndrome
- Pilocarpine (Isoptocarpine)
- Used as a Miotic agent in Glaucoma
- Used in Sweat Chloride test for Cystic Fibrosis evaluation
- Indicated in Xerostomia in Sjogren Syndrome
- Cevimeline
VII. References
- Olson (2020) Clinical Pharmacology, Medmaster, Treasure Island, Fl, p. 24
Images: Related links to external sites (from Bing)
Related Studies
| bethanechol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| BETHANECHOL 10 MG TABLET | Generic | $0.20 each |
| BETHANECHOL 25 MG TABLET | Generic | $0.27 each |
| BETHANECHOL 5 MG TABLET | Generic | $0.22 each |
| BETHANECHOL 50 MG TABLET | Generic | $0.44 each |