II. Epidemiology
- Rare
III. Pathophysiology
- Secondary Granulomatous inflammatory reaction to chronic genitourinary infection in Immunocompromised patients
- Associated with chronic infections (e.g. E. coli and other Gram Negatives)
- Infections may involve the Kidney and Retroperitoneum, Bladder, Prostate, ureter, Kidney, and female genital tract
IV. Labs
- Hallmark finding is foamy histiocytes with Basophilic inclusions (Michaelis-Gutmann bodies)
V. Management
- Treated with Antibiotics and surgical excision, correction of Immunosuppression
- Antibiotic management with Ciprofloxacin or trimethoprim-sulfamethoxazole
- Concurrent management with Bethanechol chloride which improves Antibiotic efficacy
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Definition (NCI) | An inflammatory reaction characterized by the presence of papules or nodules usually in the genitourinary tract. It is usually a reaction to an infection. Morphologically, it consists of foamy histiocytes and characteristic basophilic inclusion bodies called Michaelis-Gutmann bodies. |
Definition (MSH) | The formation of soft patches on the mucous membrane of a hollow organ, such as the urogenital tract or digestive tract. |
Concepts | Pathologic Function (T046) |
MSH | D008287 |
SnomedCT | 264545007, 50707001 |
English | Malacoplakia, Malacoplakias, Malakaplakia, Malakoplakia (qualifier value), Malakaplakia (qualifier value), Malakoplakia, Malakoplakias, Malacoplakia [Disease/Finding], malacoplakia, malakoplakia, Malakoplakia (morphologic abnormality), Malacoplakia, NOS, Malakoplakia, NOS |
Swedish | Malakoplaki |
Czech | malakoplakie |
Finnish | Malakoplakia |
Russian | MALAKOPLAKIIA, МАЛАКОПЛАКИЯ |
Spanish | Malacoplasia, Malacoplaquia, malacoplaquia (anomalía morfológica), malacoplaquia (calificador), malacoplaquia, malacoplasia |
Portuguese | Malacoplasia, Malacoplaquia |
Polish | Malakoplakia |
Japanese | マラコプラキア, 軟斑性膀胱炎, 軟斑性膀胱カタル |
Norwegian | Malakoplaki |
French | Malacoplasie, Malakoplakie, Malakoplasie |
German | Malakoplakie |
Italian | Malacoplachia |
Dutch | Malacoplakie, Malakoplakia |