II. Characteristics
- Forms in Bone Marrow from Myeloblasts as with other Granulocytes (Neutrophils, Eosinophils, Monocytes)
- Basophil granules contain Heparin, vasoactive amines (Histamines, 5-Hydroxytryptamine)
- Released agents increase vascular permeability, allowing inflammatory agents to reach injured tissue
- Function: Immediate Allergic Response
- Similar mechanism of action to Mast Cells
- Related to delayed Hypersensitivity response
- Activated on binding IgE-Antigen complexes via high affinity receptors (FceRI)
- Activation results in release of inflammatory mediators contained in its secretory granules
- Immediate release of preformed mediators (e.g. Histamine, Bradykinin) within first 5 minutes
- Leukotriene C4 released within 5-30 minutes, and results in bronchoconstriction
- Releases Cytokines TNF-alpha and IL4 within hours
- Chemotactic factors attract Neutrophil, Eosinophil
III. Labs: Morphology on Blood Smear
- Granulocyte cytoplasm stains darkly with Wright Stain
- Two lobed nucleus
- Diameter: 5-7 microns
IV. Interpretation: Normal Levels
- Range: 0.4-1.0% (Least common Leukocyte)
V. Causes: Increased Basophils (Basophilia)
- Viral Infections (e.g. Varicella)
- Hodgkin's Lymphoma
- Hemolytic Anemia
- Following splenectomy
- Myeloproliferative disease
- Inflammatory processes
- Inflammatory Bowel Disease
- Chronic dermatitis
- Asthma
- Chronic Sinusitis
- Endocrine causes
- Hypothyroidism
- Increased Estrogen
VI. Causes: Decreased Basophils
- Stress
- Hypersensitivity Reaction
- Corticosteroids
- Pregnancy
- Hyperthyroidism
VII. References
- Mahmoudi (2014) Immunology Made Ridiculously Simple, MedMaster, Miami, FL
- Siracusa (2013) J Allergy Clin Immunol 132(4): 789-801 +PMID: 24075190 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
| Definition (MSHCZE) | Bazofilní granulocyt. Druh bílé krvinky (leukocytu), jehož funkce není zcela jasná, snad ovlivňuje srážení krve v místě zánětu. Při vyšetření diferenciálu je b. nejméně četným druhem, krvinka se „ráda“ barví zásaditým barvivem. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ ) |
| Definition (NCI_NCI-GLOSS) | A type of immune cell that has granules (small particles) with enzymes that are released during allergic reactions and asthma. A basophil is a type of white blood cell and a type of granulocyte. |
| Definition (MSH) | Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes. |
| Definition (CSP) | granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes; contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. |
| Concepts | Cell (T025) |
| MSH | D001491 |
| SnomedCT | 30061004 |
| HL7 | BPH |
| LNC | LP14328-6, LP21273-5, MTHU012774 |
| English | Basophils, Basophil, segmented, basophilic granulocyte, basophilic leukocyte, Basophil leukocyte, basophils, basophil, Basophil, Basophil, segmented (cell) |
| Spanish | basófilo, segmentado, basófilo, segmentado (célula), basófilo, granulocito basófilo, Basófilos |
| French | Polynucléaires basophiles, Granulocyte basophile, PNB (Polynucléaire Basophile), Basophiles, Polynucléaire basophile, Granulocytes basophiles |
| Swedish | Basofiler |
| Czech | bazofily, granulocyty bazofilní |
| Finnish | Basofiilit |
| Russian | LEIKOTSITY BAZOFIL'NYE, GRANULOTSITY BAZOFIL'NYE, BAZOFILY, БАЗОФИЛЫ, ГРАНУЛОЦИТЫ БАЗОФИЛЬНЫЕ, ЛЕЙКОЦИТЫ БАЗОФИЛЬНЫЕ |
| Croatian | BAZOFILI |
| Latvian | Bazofili |
| Polish | Bazofile, Granulocyty zasadochłonne |
| Norwegian | Basofile leukocytter, Leukocytter, basofile, Basofile celler |
| German | Basophile Leukozyten, Basophile |
| Italian | Basofili |
| Dutch | Basofiel, Basofiele leukocyt, Basofielen |
| Portuguese | Basófilos |
Ontology: Blood basophil count (lab test) (C0200641)
| Concepts | Laboratory Procedure (T059) |
| SnomedCT | 165529004, 142941000, 165526006, 142937004, 42351005 |
| English | Basophils, Basophil count NOS, blood basophil count, blood basophil count (lab test), basophil count, Blood basophil count (lab test), basophils count, Basophil count NOS (procedure), Basophil count, Basophil count (procedure), Basophil count [dup] (procedure) |
| Italian | Conta basofila, Basofili |
| Dutch | basofielen, basofielentelling |
| French | Basophiles, Numération des basophiles |
| German | basophile Granulozyten, Basophilenzahl |
| Portuguese | Basófilos, Número de basófilos |
| Spanish | Basófilos, recuento de basófilos, SAI (procedimiento), recuento de basófilos, SAI, Basophil count NOS, recuento de basófilos (procedimiento), recuento de basófilos, Recuento de basófilos |
| Japanese | 好塩基球, 好塩基球数, ｺｳｴﾝｷｷｭｳｽｳ, ｺｳｴﾝｷｷｭｳ |
| Czech | Bazofily, Počet bazofilů |
| Hungarian | Bazofilek, Bazofil szám |
Ontology: Basophilia (C0702266)
| Concepts | Finding (T033) |
| ICD9 | 288.65 |
| ICD10 | D72.824 |
| SnomedCT | 142939001, 65209002 |
| English | BASOPHILIA, basophilia, basophilia (diagnosis), basophilic leukocytosis, basophilia disorder, basophilia test result, Circulating basophils increased above normal range, Basophilic leukocytosis, Basophilia (finding), Basophilic leucocytosis, Basophilia |
| Italian | Basofilia |
| Japanese | 好塩基球増加症, ｺｳｴﾝｷｷｭｳｿﾞｳｶｼｮｳ |
| Portuguese | BASOFILIA, Basofilia |
| Spanish | BASOFILIA, basofilia (hallazgo), basofilia, leucocitosis con basofilia, Basofilia |
| French | BASOPHILIE, Basophilie |
| German | BASOPHILIE, Basophilie |
| Czech | Bazofilie |
| Hungarian | basophilia |
| Dutch | basofilie |
