II. Indications

  1. Hypercoagulable state evaluation

III. Normal

  1. Activity: 80-120% of normal activity
  2. Level: 17-30 mg/dl

IV. Increased

V. Decreased

  1. Hereditary Antithrombin III deficiency
  2. Disseminated Intravascular Coagulation
  3. Pulmonary Embolus
  4. Cirrhosis
  5. Thrombolysis
  6. Chronic liver failure
  7. Post-surgery
  8. Nephrotic Syndrome
  9. Sepsis
  10. Medications
    1. Intravenous Heparin use longer than 3 days
    2. Oral Contraceptive Use

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Ontology: Antithrombin III (C0003438)

Definition (MSH) A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Definition (NCI) Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation.
Definition (CSP) blood glycoprotein which inhibits thrombin and other blood coagulation factors; important to maintenance of normal blood fluidity.
Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH D000990
SnomedCT 34086003, 46553007, 5485005, 386959004, 395241004, 259743002, 109001008
LNC LP15394-7, MTHU008554
English Antithrombin III, Antithrombin II, Heparin Co Factor I, Heparin Co-Factor I, Cofactor I, Heparin, Heparin Cofactor I, Serpin C1, Antithrombin III [Chemical/Ingredient], antithrombin iii, factor inhibitors xa, antithrombin, ATIII, Antithrombin-III, Serine-Cysteine Proteinase Inhibitor Clade C Member 1, SERPINC1, antithrombin III, Antithrombin III preparation (substance), Antithrombin III product (product), Heparin cofactor I (substance), Antithrombin II (substance), Antithrombin, Antithrombin III product, Heparin cofactor I, Antithrombin III (substance), Antithrombin III preparation (product), Antithrombin III preparation, Heparin cofactor I -RETIRED-, Antithrombin II -RETIRED-
Swedish Antitrombin III
Czech antithrombin III
Spanish cofactor de la heparina I, antithrombin III, antithrombin III (producto), cofactor I de heparina - RETIRADO -, cofactor I de heparina - RETIRADO - (concepto no activo), antitrombina II (sustancia), antitrombina II - RETIRADO - (concepto no activo), preparado de antitrombina III, preparado de antitrombina III (sustancia), antitrombina II, antitrombina II - RETIRADO -, antitrombina III (sustancia), antitrombina III, preparado con antitrombina III (producto), preparado con antitrombina III, preparado de antitrombina III (producto), Antitrombina III, Cofactor I de Heparina
Finnish Antitrombiini III
Italian Antitrombina II, Inibitore del fattore Xa, Eparina cofattore I, Antitrombina III
Japanese 抗トロンビン2, 抗トロンビン3, ヘパリン補因子I, アンチトロンビンIII, アンチトロンビン2, アンチトロンビンII, アンチトロンビン3
French Inhibiteur du facteur Xa, Antithrombine progressive, Cofacteur-I de l'héparine, Antithrombine III, Antithrombine-III, Protéine antithrombine-III, Co-facteur-I de l'héparine, Serpine C1
Polish Antytrombina III, AT III
Portuguese Cofator I de Heparina, Antitrombina III
German Antithrombin III, Antithrombin II, Heparin-Cofaktor I