Antithrombin III deficiency

Aka: Antithrombin III deficiency

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II. Pathophysiology

  1. Antithrombin III normally inhibits
    1. Factor IXa
    2. Factor Xa
    3. Factor XIa
    4. Factor XIIa
    5. Thrombin
  2. Enhanced by Heparin

III. Epidemiology

  1. Heterozygotes have 25-50% ATIII functional levels
  2. First episode of thrombosis occurs ages 10-30 years

IV. Complications

  1. Venous Thromboembolism

V. Labs

  1. Functional level Antithrombin III

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