Extrinsic Clotting Pathway

Aka: Extrinsic Clotting Pathway

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II. Pathophysiology

  1. Initiated by disrupted cell membranes

III. Images

  1. Overview
    1. pathClottingCascade.png
  2. Full Thrombosis Pathway
    1. ThrombosisPathway.png

IV. Physiology: Extrinsic Clotting Pathway

  1. Initiated by disrupted cell membranes
  2. Damaged cells (including vascular endothelial cells) release Tissue Thromboplastin
  3. Pathway is relatively rapid with Blood Clotting occuring within 15 seconds
    1. Factor VII, Factor V and Calcium combine to trigger conversion of Factor X to Xa
    2. Factor Xa then proceeds into the Common Clotting Pathway, generating Thrombin and then Fibrin

V. Labs: Prolonged Times in Extrinsic Clotting Pathway Disorders

  1. Prothrombin Time

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