II. Mechanism

III. Pharmacokinetics

  1. Half-Life: 1 hour
  2. Renally excreted

IV. Efficacy

  1. Idarucizumab is highly effective (100%) in initial studies and FDA approval
  2. Complete Dabigatran reversal within minutes with effect lasting >24 hours, without Hypercoagulable adverse effects

V. Dosing

  1. Idarucizumab 5 gram IV

VI. Disadvantages

  1. Expensive ($3500 wholesale in 2016)

VII. Adverse Effects

  1. Thrombosis risk 6% at 30 days
  2. Mild adverse effects (Headache, skin and infusion site irritation)

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