Definition (NCI)
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A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA. These reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.
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Definition (NCI)
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A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.
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Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Bleomycin damages DNA and may kill rapidly growing cancer cells. It is a type of antineoplastic antibiotic.
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Definition (MSH)
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A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
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Definition (CSP)
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complex of related glycopeptide antibiotics from Streptomyces verticillus; inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
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Definition (PDQ)
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A mixture of glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39139&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39139&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C313" NCI Thesaurus)
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Concepts |
Amino Acid, Peptide, or Protein
(T116)
, Antibiotic
(T195)
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MSH |
D001761
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SnomedCT |
391855008, 372843005, 76591000 |
English |
Bleomycins, bleomycin, Bleomycin [Chemical/Ingredient], blm, Bleomycin - chemical (substance), Bleomycin - chemical, Bleo, BLEOMYCIN, Bleomycin (product), Bleomycin (substance), Bleomycin, BLM, BLEO, Bleomycin Antibiotic |
Swedish |
Bleomycin
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Czech |
bleomycin
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Finnish |
Bleomysiini
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French |
Bléomycines, Bléomycine |
Italian |
Bleomicine, Bleomicina |
Russian |
BLEOMITSIN, БЛЕОМИЦИН |
Japanese |
ブレオマイシン
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Polish |
Bleomycyna
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Spanish |
bleomicina (producto), bleomicina (sustancia), bleomicina, Bleomicina |
German |
Bleomycin
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Portuguese |
Bleomicina
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