II. Medications: Mitotic Inhibitors
- Vinca Alkaloids
- Vinblastine (Velban)
- Vincristine (Oncovin)
- Vinorelbine
- Taxanes
- Topoisomerase 1 Inhibitors
- Topotecan (Hycamptin)
- Irinotecan (Camtosar)
- Irinotecan Liposome (Onivyde)
- Topoisomerase 2 Inhibitors
- Anthracyclines (e.g. Daunorubicin, Doxorubicin, Idarubicin, Mitoxantrone)
- Etoposide (VePesid, VP-16)
- Teniposide (Vumon, VM-26)
- Other
III. Medications: Plant-Based Alkyloids
- Subset of the mitotic inhibitors listed above
- Vinca Alkaloids
- Inhibits Mitosis (Metaphase arrest)
- Cause disassembly of microtubules
- Periwinkle Plant (Vinca rosea) derivatives include Vinblastine and Vincristine
-
Podophyllotoxins
- Block cells in S-G2 phase of Cell Cycle
- DNA degradation
- Nucleoside transport inhibition
- Mitochondrial electron transport inhibition
- Mayapple plant (Podophyllum peltatum) derivatives include Etoposide and Teniposide
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| Definition (NCI_NCI-GLOSS) | A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. |
| Definition (NCI) | An agent that inhibits tumor growth by interfering with mitotic processes or the assembly of the mitotic machinery. |
| Definition (CSP) | agent that inhibits or prevents mitosis. |
| Definition (MSH) | Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D050256 |
| SnomedCT | 108793003, 372542006, 108932001, 372556008 |
| Czech | antimitotické látky, antimitotické léky, antimitotika |
| Finnish | Antimitoottiset aineet |
| Italian | Antimitotici |
| Russian | ANTIMITOTICHESKIE SREDSTVA, АНТИМИТОТИЧЕСКИЕ СРЕДСТВА |
| Swedish | Antimitotika |
| English | antimitotic agent, antimitotic, antimitotic drugs, Antimitotic agents, mitotic inhibitor, Mitotic inhibitor (product), Mitotic inhibitor (substance), Mitotic inhibitor, Antimitotic agent (product), Antimitotic agent (substance), Antimitotic agent, Antimitotic Agents, Microtubular Function Inhibitors, Mitosis Inhibitor Agents, Mitosis Inhibitor Drugs, Mitosis Inhibitors, Mitotic Inhibitor Agents, Mitotic Inhibitor Drugs, Mitotic Inhibitors, Antimitotic Agent, Agents, Antimitotic, Antimitotic Drugs, Antimitotics, Drugs, Antimitotic |
| Polish | Środki przeciwmitotyczne |
| Japanese | 有糸分裂阻害剤, 抗ミトティック剤, 有糸分裂阻害薬 |
| Spanish | Antimitósicos, Agentes Antimitóticos, Fármacos Antimitóticos, agente antimicótico (sustancia), agente antimicótico, agente antimitótico (producto), agente antimitótico (sustancia), agente antimitótico, antimitótico, inhibidor de la mitosis (sustancia), inhibidor de la mitosis, inhibidor mitótico (producto), inhibidor mitótico (sustancia), inhibidor mitótico, Antimitóticos |
| Portuguese | Agentes Antimitóticos, Antimitóticos |
| German | Mitosehemmer, Antimitotika |
| French | Antimitotiques, Agents antimitotiques, Anti-mitotiques, Médicaments antimitotiques |
Ontology: Vinca Alkaloids (C0042672)
| Definition (NCI_NCI-GLOSS) | A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A vinca alkaloid is a type of mitotic inhibitor and a type of antimicrotubule agent. |
| Definition (MSH) | A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS. |
| Definition (CSP) | nitrogenous basic compounds produced by the Madagascar periwinkle; they are cytotoxic and cell cycle specific for the M phase of cell division. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D014748 |
| SnomedCT | 349850001, 61864009 |
| English | Alkaloids, Vinca, Vinca Alkaloids, vinca alkaloids, vinca alkaloids (medication), Vinca Alkaloids [Chemical/Ingredient], Vinca alkaloid, Vinca alkaloid (substance), vinca alkaloid, Vinca Alkaloid Compound |
| German | Vincaalkaloide, Vinca-Alkaloide |
| Swedish | Vinkaalkaloider |
| Czech | Vinca - alkaloidy |
| Finnish | Vinka-alkaloidit |
| Russian | BARVINKA ALKALOIDY, БАРВИНКА АЛКАЛОИДЫ |
| Croatian | Not Translated[Vinca Alkaloids] |
| Polish | Alkaloidy barwinka |
| Portuguese | Alcaloides de Vinca |
| Spanish | alcaloide de la vinca (sustancia), alcaloide de la vinca, Alcaloides de la Vinca |
| French | Alcaloïdes pervenche |
| Italian | Alcaloidi della vinca |
Ontology: Topoisomerase Inhibitors (C0598317)
| Definition (MSH) | Compounds that inhibit the activity of DNA TOPOISOMERASES. |
| Definition (NCI) | Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis. |
| Definition (NCI_NCI-GLOSS) | A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D059003 |
| SnomedCT | 108780008, 372537003 |
| English | topoisomerase inhibitors, topoisomerase inhibitors (medication), Topoisomerase Inhibitors, DNA, Inhibitors, Topoisomerase, DNA Topoisomerase Inhibitors, Inhibitors, DNA Topoisomerase, topoisomerase inhibitor, Topoisomerase inhibitor (product), Topoisomerase inhibitor (substance), Topoisomerase inhibitor, Topoisomerase Inhibitor, Topoisomerase Inhibitors |
| French | Inhibiteurs des ADN topo-isomérases, Inhibiteurs des topoisomérases, Inhibiteurs des ADN topoisomérases, Inhibiteurs des topo-isomérases |
| German | Topoisomerase-Inhibitoren, DNA-Topoisomerase-Inhibitoren |
| Czech | DNA topoisomerasy - inhibitory, DNA-topoisomerasy - inhibitory, topoisomerasy - inhibitory |
| Italian | Inibitori delle topoisomerasi |
| Spanish | Inhibidores de Topoisomerasa, inhibidor de la topoisomerasa (sustancia), inhibidor de la topoisomerasa, inhibidor de topoisomerasa (producto), inhibidor de topoisomerasa (sustancia), inhibidor de topoisomerasa |
| Russian | TOPOIZOMERAZY INGIBITORY, INGIBITORY TOPOIZOMERAZ, ДНК ТОПОИЗОМЕРАЗ ИНГИБИТОРЫ, ИНГИБИТОРЫ ТОПОИЗОМЕРАЗ, ТОПОИЗОМЕРАЗЫ ИНГИБИТОРЫ, DNK TOPOIZOMERAZ INGIBITORY |
| Portuguese | Inibidores da Topoisomerase |
| Polish | Inhibitory topoizomerazy |
Ontology: Taxanes (C0796419)
| Definition (NCI_NCI-GLOSS) | A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent. |
| Concepts | Organic Chemical (T109) |
| MSH | D043823 |
| Czech | taxany |
| Portuguese | Taxanos |
| Spanish | Taxanos |
| German | Taxane |
| English | taxanes, taxanes (medication), Taxanes, taxane, Taxane Compound |
| French | Taxanes, Diterpènes de type taxane |
| Italian | Taxani |
