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Definition (NCI_NCI-GLOSS)
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A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.
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Definition (NCI)
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An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
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Definition (MSH)
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An anthracenedione-derived antineoplastic agent.
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Definition (CSP)
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1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D008942
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| SnomedCT |
108791001, 386913001 |
| English |
DHAQ, Mitozantrone, 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-, 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone, 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione, Dihydroxyanthracenedione, mitoXANTRONE, Mitoxantrone [Chemical/Ingredient], mitozantrone, mitoXANtrone, Mitoxantrone, MITOXANTRONE, mitoxantrone, DHAD, Mitoxantrone product, Mitozantrone product, Mitoxantrone (product), Mitoxantrone (substance), dihydroxyanthracenedione |
| Swedish |
Mitoxantron
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| Czech |
mitoxantron
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| Finnish |
Mitoksantroni
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| Russian |
MITOZANTRON, MITOKSANTRON, МИТОЗАНТРОН, МИТОКСАНТРОН |
| Japanese |
ミトザントロン, ノバントロン, 塩酸ミトキサントロン, ミトキサントロン塩酸塩, ミトキサントロン |
| Italian |
Mitozantrone, Mitoxantrone |
| Polish |
Mitoksantron
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| Spanish |
mitoxantrona (producto), mitoxantrona (sustancia), mitoxantrona, Mitoxantrona, Mitozantrona |
| French |
Mitoxantrone
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| German |
Mitoxantron, Mitozantron |
| Portuguese |
Mitoxantrona, Mitozantrona |
