II. Epidemiology

  1. Most common Acute Leukemia of adults (80% of cases)

III. Pathophysiology

  1. Myelodysplastic disorder or preleukemia in 25%
    1. Anemia or Cytopenia precedes Leukemia by years

IV. Risk Factors: Prior Chemotherapy

  1. Agents
    1. Alkylating Agents
      1. Chlorambucil
      2. Cyclophosphamide
    2. Nitrosourea
    3. Procarbazine
  2. Conditions
    1. Hodgkin's Disease
    2. Multiple Myeloma
    3. Ovarian Cancer

V. Symptoms

  1. See Acute Leukemia
  2. Constitutional symptoms
    1. Fever
    2. Fatigue
    3. Weight loss
  3. Anemia-related symptoms
    1. Shortness of Breath
    2. Exertional Chest Pain
  4. Thrombocytopenia related symptoms
    1. Excessive bleeding or Bruising

VI. Signs

VII. Labs

  1. See Acute Leukemia
  2. Peripheral Smear findings specific for Acute Myelogenous Leukemia
    1. Immature Myeloblasts (blast cells) on Peripheral Smear
    2. Auer rods may be found (inconsistent)

VIII. Diagnosis

  1. Sources
    1. Peripheral Blood Smear
    2. Bone Marrow Biopsy
  2. Studies to distinguish between AML and ALL
    1. Flow cytometry with immunophenotyping
      1. Sorts and counts cells by cell surface markers
    2. Cytogenetic testing
      1. Chromosome evaluation (karyotype or fluorescence in situ hybridization analysis)

IX. Management

  1. Induction of Severe Myelosuppression (60-80% remission)
    1. Cytarabine
    2. Daunorubicin or Mitoxantrone or amsacrine
    3. 6-Thioguanine
  2. Repeat cycles of consolidation Chemotherapy
  3. Bone Marrow Transplantation improves survival

X. Management: Surveillance of survivors treated with Chemotherapy and radiation

  1. Complete Blood Count with differential
    1. Every 1-2 months for 3 years THEN
    2. Every 3-6 months for up to 5 years
  2. Cardiac testing
    1. Echocardiogram every 2 years
    2. Electrocardiogram every 2 years
    3. MUGA Scan (Multi Gated Acquisition Scan, radionuclide angiography) every 5 years
    4. Holter Monitor every 5 years

XI. Management: Surveillance of survivors miscellaneous

XII. Complications

  1. CNS Leukemia (10-20%)

XIII. Prognosis

  1. Remission 9 months to 2 years after Chemotherapy
  2. Five year survival
    1. Age <50 years: 55%
    2. Age >50 years: 14%
  3. Relapse is common
    1. Much less amenable to treatment
    2. Median survival after relapse: 3-6 months
  4. Factors suggestive of better prognosis
    1. Chromosomal abnormalities: t(8;21), t(15;17), inv 16
  5. Factors suggestive of poor prognosis
    1. Age over 60 years
    2. Chromosomal abnormalities: -5, -7, t(9;22)
    3. Acute Promyelocytic Leukemia
    4. Monocytic or myelomonocytic Leukemia
    5. Preleukemia history
    6. Cytotoxic Chemotherapy for prior malignancy

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Acute Erythroblastic Leukemia (C0023440)

Definition (NCI) Acute erythroid leukemia characterised by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present. -- 2003
Definition (NCI) The progression of a myelodysplastic syndrome in which there is erythroid predominance into erythroleukemia (M6a or erythroleukemia, erythroid/myeloid).
Definition (NCI_NCI-GLOSS) Cancer of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.
Definition (NCI) An acute myeloid leukemia characterized by a predominant immature erythroid population. There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. Severe anemia is a common symptom. This leukemia usually follows an aggressive clinical course. (WHO, 2001)
Definition (NCI) Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. -- 2003
Definition (NCI_CDISC) A progressive, proliferative disease of blood cells, originating from immature erythroid cells.
Definition (MSH) A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
Definition (CSP) myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
Concepts Neoplastic Process (T191)
MSH D004915
ICD10 M9840/3 , C94.0, C94.00
SnomedCT 93451002, 188752009, 190043009, 190040007, 14317002, 36449005
English Erythroleukemias, Acute Erythroblastic Leukemias, Di Guglielmo Disease, Di Guglielmo's Disease, Di Guglielmos Disease, Disease, Di Guglielmo, Erythremic Myeloses, Erythremic Myelosis, Erythroblastic Leukemia, Acute, Erythroblastic Leukemias, Acute, Erythroleukemia, Leukemia, Acute Erythroblastic, Leukemia, Erythroblastic, Acute, Leukemia, Myeloid, Acute, M6, Leukemias, Acute Erythroblastic, Myeloid Leukemia, Acute, M6, Myeloses, Erythremic, Disease, Di Guglielmo's, DI GUGLIELMO'S SYNDROME, ERYTHRAEMIC MYELOSIS, ERYTHROLEUKEMIA, Myelosis, Erythremic, Erythroleukaemia NOS, Erythroleukaemias, Erythroleukemia NOS, [M]Erythroleukaemia NOS, [M]Erythroleukaemias, [M]Erythroleukemia NOS, erythremic myelosis, MYELOID LEUKEMIA ACUTE M 06, DI GUGLIELMOS DIS, LEUKEMIA MYELOID ACUTE M 06, DI GUGLIELMO DIS, [M]Erythroleukaemia, [M]Erythroleukemia, DiGugliemo syndrome, Erythroleukemia without mention of remission, erythroleukemia, leukemia erythroleukemia (di Guglielmo's disease), acute myelogenous leukemia M6 type, di Guglielmo's disease, acute myelogenous leukemia M6 type (diagnosis), erythroleukemia (diagnosis), AML M6 type, Di Guglielmo's syndrome, Syndrome DiGuglielmo's, Myelosis erythremic, acute myelogenous leukemia (AML) M6 type, Erythroleukemia (Erythroid/Myeloid), Erythroleukemia, Erythroid/Myeloid, Leukemia, Erythroblastic, Acute [Disease/Finding], acute erythroblastic leukemia, aml m6, di guglielmo disease, erythroleukaemia, diguglielmo's syndrome, erythroid leukemia acute, Acute erythroid leukemia NOS, AEL, M6b, M6a, PEL, Di Guglielmo Syndrome, Acute Erythremic Myelosis, [M]Erythroleukemias, [M]Erythroleukemia NOS (morphologic abnormality), [M]Erythroleukemias (morphologic abnormality), ERYTHROBLASTIC LEUKEMIA, M6 ACUTE MYELOID LEUKEMIA, ACUTE ERYTHROBLASTIC LEUKEMIA, LEUKEMIA, ERYTHROID, MALIGNANT, Myelosis erythraemic, Di Guglielmo's disease, Erythremic myelosis, Erythraemic myelosis, Erythroleukaemia, FAB M6, M6 - Acute erythroleukaemia, M6 - Acute erythroleukemia, Acute erythroid leukaemia, Acute erythroid leukemia, Di Guglielmo disease [obs], Erythroleukaemia, FAB M6, Erythroleukemia, FAB M6, Acute erythraemia [obs], Acute erythraemic myelosis [obs], Acute erythremia [obs], Acute erythremic myelosis [obs], Acute myeloid leukaemia, M6 type, Acute myeloid leukemia, M6 type (morphologic abnormality), Acute myeloid leukemia, M6 type, M6B, AML M6, erythremic; myelosis, acute, erythremic; myelosis, myelosis; erythremic, acute, myelosis; erythremic, Di Guglielmo, Erythremic myelosis, NOS, Acute Erythroblastic Leukemia, Acute Erythroid Leukemia, Acute Myeloid Leukemia M6b, Erythroblastic Leukemia, M6 Acute Myeloid Leukemia, Pure Erythroid Leukemia, Erythroleukemia, FAB M6 (disorder), Disorder: Erythroleukemia, FAB M6 (disorder), Acute erythremic myelosis
French ERYTHROLEUCEMIE, Myélose érythrémique, Myélose érythrémique aiguë, Erythroleucémie aiguë, Leucémie aiguë érythroïde, Erythroleucémie, Leucémie érythroblastique aigüe, Leucémie myéloïde aigüe M6, Myélose érythrémique aigüe de Di Guglielmo, Leucémie érythroblastique aiguë, Leucémie aigüe myéloïde M6, MYELOSE ERYTHREMIQUE, SYNDROME DE DI GUGLIELMO, Leucémie érythrocytaire, Érythroleucémie, Maladie de Di Guglielmo, LAM avec différenciation érythroblastique, Leucémie aiguë myéloïde M6, Leucémie myéloïde aiguë M6, LAM M6, Myélose érythrémique aiguë de Di Guglielmo
Portuguese ERITROLEUCEMIA, MIELOSE ERITREMICA, Leucemia eritróide aguda, Mielose eritrémica, Síndrome de Di Guglielmo, Síndrome de DiGuglielmo, SINDROME DI GUGLIELMO, Leucemia Mieloide Aguda M6, Eritroleucemia, Doença de Di Guglielmo, Leucemia Eritroblástica Aguda, Mielose Eritrêmica
Spanish ERITROLEUCEMIA, MIELOSIS ERITREMICA, morfología: leucemia mielocítica aguda, tipo M6, Mielosis eritrémica, Síndrome de Di Guglielmo, Leucemia eritroide aguda, SINDROME DE DI GUGLIELMO, [M]eritroleucemias, [M]eritroleucemias (anomalía morfológica), [M]eritroleucemia, SAI, [M]eritroleucemia, SAI (anomalía morfológica), (M)eritroleucemia, enfermedad de Di Guglielmo, eritremia aguda, eritroleucemia, FAB M6 (trastorno), eritroleucemia, leucemia eritroide aguda, leucemia mielocítica aguda, tipo M6, mielosis eritrémica aguda, mielosis eritrémica, morfología: leucemia mielocítica aguda, tipo M6 (anomalía morfológica), eritroleucemia, FAB M6, Eritroleucemia, Enfermedad de Di Guglielmo, Leucemia Eritroblástica Aguda, Leucemia Mieloide Aguda M6, Mielosis Eritrémica
Dutch acute erythroïde leukemie, erythraema myelosis, myelose erythremisch, syndroom van Diguglielmo, Di Guglielmo's syndroom, erythroleukemie, erythremische myelosis, myelosis erythremisch, erytroleukemie, erytremisch; myelose, acuut, erytremisch; myelose, myelose; erytremisch, acuut, myelose; erytremisch, Acute erytroblastenleukemie, Di Guglielmo-leukemie, Erytremische myelose, Erytroblastenleukemie, acute, Erytroleukemie, Leukemie, acute erytroblasten-, Leukemie, myeloïde acute, M6, Myeloïde leukemie, acute, M6
German akute erythroide Leukaemie, Erythroleukemie, Myelose, erythraemisch, erythraemische Myelose, Di Guglielmo-Syndrom, Syndrom, Di Guglielmo, DI-GUGLIELMO SYNDROM, ERYTHROLEUKAEMIE, ERYTHROLEUKAEMISCHE MYELOSE, LEUKÄMIE MYELOISCHE AKUTE M 06, MYELOISCHE LEUKÄMIE AKUTE M 06, Erythroleukaemie, Di-Guglielmo-Krankheit, Erythrämische Myelose, Erythroblastenleukämie, akute, Erythroblastische Leukämie, akute, Erythroleukämie, Leukämie, myeloische, akute, M6, Myeloische Leukämie, akute, M6
Italian Sindrome di Di Guglielmo, Leucemia eritroide acuta, Malattia di Di Guglielmo, Leucemia acuta mieloide M6, Eritroleucemia, Mielosi eritremica, Leucemia eritroblastica acuta
Japanese 急性赤白血病, キュウセイセキハッケツビョウ, セキハッケツビョウ, セッケツビョウセイコツズイショウ, ディ・グリエルモ病, ディ・グリエルモ症候群, ディグリエルモショウコウグン, Di Guglielmo病, 白血病-急性赤芽球性, M6急性骨髄性白血病, 急性M6骨髄性白血病, 急性赤芽球性白血病, 赤白血病, 赤血病性骨髄症, 赤血症性骨髄症, 赤血白血病, 白血病-急性骨髄性M6, 白血病-赤芽球性-急性, 白血病-骨髄性-急性-M6, 赤芽球性白血病-急性, 骨髄性白血病-急性-M6, 骨髄症-赤血病性
Swedish Leukemi, erytroblastisk, akut
Czech leukémie erytroblastická akutní, erytroleukémie, leukémie myeloidní akutní M6, Di Guglielmova nemoc, erytrémie, Erytremická myelóza, Erytroleukemie, Akutní erytroidní leukemie, Di Gugliemův syndrom, Syndrom Di Gugliemův
Finnish Akuutti erytroblastinen leukemia
Polish Szpikowica czerwonokrwinkowa, Białaczka erytroblastyczna ostra
Hungarian Heveny erythroid leukaemia, Erythemás myelosis, Acut erythroid leukemia, Erythraemiás myelosis, Erythemás mielózis, Erythraemiás mielózis, Di Guglielmo-syndroma, Erythroleukaemia, DiGuglielmo-syndroma
Norwegian Akutt myelogen leukemi M6, Erytroleukemi

Ontology: Leukemia, Myelocytic, Acute (C0023467)

Definition (MEDLINEPLUS)

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukemia (AML), there are too many of a specific type of white blood cell called a myeloblast.

AML is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated. Possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation.

Symptoms of AML include:

  • Fever
  • Shortness of breath
  • Easy bruising or bleeding
  • Bleeding under the skin
  • Weakness or feeling tired
  • Weight loss or loss of appetite

Tests that examine the blood and bone marrow diagnose AML. Treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back.

NIH: National Cancer Institute

Definition (NCI_NCI-GLOSS) An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.
Definition (NCI) A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).
Definition (NCI) This term refers to acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. It includes entities classified according to the French-American-British classification scheme.
Definition (CSP) leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.
Definition (CSP) acute leukemia arising from myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.
Definition (MSH) Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Concepts Neoplastic Process (T191)
MSH D015470
ICD9 205.0
ICD10 C92.0 , M9861/3, C92.00
SnomedCT 17788007, 91861009, 154591002, 277600006, 413443009
English Acute Nonlymphoblastic Leukemia, Acute Nonlymphoblastic Leukemias, Acute Nonlymphocytic Leukemias, Leukemia, Acute Nonlymphoblastic, Leukemia, Acute Nonlymphocytic, Leukemia, Myelocytic, Acute, Leukemias, Acute Nonlymphoblastic, Leukemias, Acute Nonlymphocytic, Nonlymphoblastic Leukemias, Acute, Nonlymphocytic Leukemia, Acute, Nonlymphocytic Leukemias, Acute, Myeloid leukemia, acute, AML - Acute myelobl leukaemia, AML - Acute myelobl leukemia, LEUKEMIA ACUTE MYELOBLASTIC, AML, LEUKEMIA, ACUTE MYELOID, LEUKEMIA, ACUTE MYELOGENOUS, [M]Acute myeloid leukaemia, [M]Acute myeloid leukemia, Acute Myeloblastic Leukemias, Myeloid Leukemias, Acute, Nonlymphoblastic Leukemia, Acute, Myeloblastic Leukemias, Acute, Myelogenous Leukemia, Acute, Myelogenous Leukemias, Acute, Leukemia, Myelogenous, Acute, Leukemias, Acute Myeloblastic, Myelocytic Leukemias, Acute, Myeloid Leukemia, Acute, Leukemia, Acute Myeloblastic, Leukemia, Nonlymphoblastic, Acute, Leukemia, Myeloid, Acute, Myeloblastic Leukemia, Acute, Myelocytic Leukemia, Acute, Acute Myelocytic Leukemias, Leukemias, Acute Myelocytic, Leukemia, Myeloblastic, Acute, ANLL, Leukemia, Acute Myelocytic, Leukemia, Nonlymphocytic, Acute, Leukemias, Acute Myelogenous, Acute Myeloid Leukemia, Acute Myeloid Leukemias, Leukemias, Acute Myeloid, acute granulocytic leukemia, acute myelocytic leukemia, AML (acute myelogenous leukemia), acute myelogenous leukemia, acute myelogenous leukemia (diagnosis), Acute myeloid leukemia, no ICD-O subtype, Acute myeloid leukaemia, no ICD-O subtype, Non-lymphoblastic leukaemia acute, Acute myeloid leukaemia NOS, Myeloid leukaemia, acute, Non-lymphoblastic leukemia acute, Leukemia myeloblastic acute, Acute myeloid leukemia NOS, acute myelogenous leukemia (AML), Acute Myeloid Leukemia Not Otherwise Specified, AML, NOS, Acute Myeloid Leukemia, NOS, Acute Myeloid Leukemia Not Otherwise Categorized, Hematopoeitic - Acute Myleogenous Leukemia (AML), Acute Myeloid Leukemia NOS, Acute myeloblastic leukemia NOS, Leukemia, Myeloid, Acute [Disease/Finding], Leukaemia;acute myeloid, acute myeloid leukemias, acute non-lymphoblastic leukemia, non-lymphoblastic leukemia acute, acute non-lymphocytic leukemia, acute myelocytic leukaemia, acute myelogenous leukaemia, aml, acute nonlymphoblastic leukemia, acute leukemias non lymphoblastic, acute nonlymphocytic leukemia (ANLL), anll, Leukaemias acute myeloid, Leukemia, acute myeloid, Leukemia, Acute Myelogenous, Acute Myelogenous Leukemia, Leukemia, Acute Myeloid, acute myeloblastic leukemia, leukemia acute myeloblastic, acute myeloblastic leukemia (diagnosis), Acute myeloblastic leukemia (disorder), [M]Acute myeloid leukaemia (disorder), Acute myeloid leukemia, no ICD-O subtype (morphologic abnormality), Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype, Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality), Acute myeloid leukemia, NOS, Leukaemia myeloblastic acute, Acute myeloid leukemia, Acute granulocytic leukemia, Acute myelogenous leukemia, Acute myelocytic leukemia, AML - Acute myeloid leukaemia, AML - Acute myeloid leukemia, Acute myeloblastic leukaemia, Acute myeloblastic leukemia, Acute myeloid leukaemia, Acute granulocytic leukaemia, Acute myelocytic leukaemia, Acute myelogenous leukaemia, Acute myeloid leukaemia, disease, Acute myeloid leukemia, disease (disorder), Acute myeloid leukemia, disease, Acute non-lymphocytic leukaemia, Acute non-lymphocytic leukemia, acute nonlymphocytic leukemia, acute myeloid leukemia, leukemia, acute myeloid, leukemia, acute nonlymphocytic, granulocytic; leukemia, acute, leukemia; granulocytic, acute, leukemia; myelocytic, acute, leukemia; myeloid, acute, myelocytic; leukemia, acute, myeloid; leukemia, acute, Acute Myelogenous Leukemias, Acute Nonlymphocytic Leukemia, Acute Myeloblastic Leukemia, Acute Myelocytic Leukemia, AML - Acute Myeloid Leukemia, AML - Acute myeloblastic leukaemia, AML - Acute myeloblastic leukemia, Acute myeloid leukemia - category (morphologic abnormality), Acute myeloid leukemia - category, Acute myeloid leukaemia - category, Leukemias acute myeloid, Leukemia;acute myeloid, acute myeloid leukaemia
Spanish leucemia mieloide aguda, enfermedad, morfología: leucemia mielocítica aguda, no clasificada como subtipo en CIE - O, Leucemia mielógena aguda NEOM, Leucemia mieloide aguda, Leucemia aguda no linfoblástica, Leucemia mielocítica aguda, Leucemia mieloide aguda NEOM, Leucemia mieloblástica aguda, LMA, Leucemia granulocítica aguda, Leucemia no linfoblástica aguda, Leucemia Aguda Mieloide, Leucemia Mielógena Aguda, Leucemia no Linfocítica Aguda, Leucemia Mieloide Aguda, LMA - leucemia mieloide aguda, leucemia mieloblástica aguda (trastorno), leucemia granulocítica aguda, leucemia mieloblástica aguda, leucemia mielocítica aguda, leucemia mieloide aguda, enfermedad (trastorno), leucemia mieloide aguda, leucemia mielógena aguda, morfología: leucemia mielocítica aguda, no clasificada como subtipo en CIE - O (anomalía morfológica), Leucemia aguda mielógena, Leucemia mielógena aguda, leucemia mieloide aguda - categoría (anomalía morfológica), leucemia mieloide aguda - categoría
Italian Leucemie acute mieloidi, Leucemia mieloblastica acuta, Leucemia non linfoblastica acuta, Leucemia mieloide, acuta, Leucemia mieloide acuta, NAS, Leucemia mielogena acuta, Leucemia granulocitica acuta, Leucemia mielocitica acuta, Leucemia mieloide acuta
Dutch acute myeloïde leukemie NAO, acute myelocytaire leukemie, AML, leukemie myeloblastisch acuut, myeloïde leukemie, acuut, acute granulocytaire leukemie, acute myeloblastische leukemie, acute niet-lymfoblastische leukemie, niet-lymfoblastische leukemie acuut, myeloblastische leukemie acuut, acute myeloïde leukemia NAO, granulocytair; leukemie, acuut, leukemie; granulocytair, acuut, leukemie; myelocytair, acuut, leukemie; myeloïd, acuut, myelocytair; leukemie, acuut, myeloïd; leukemie, acuut, Acute myeloïde leukemie, acute myeloïde leukemie, myeloïde leukemieën acuut, Acute non-lymfocytenleukemie, Leukemie, acute niet-lymfatische, Leukemie, acute non-lymfocyten-, Leukemie, non-lymfoblastaire acute, Non-lymfoblastenleukemie, acute, Non-lymfocytenleukemie, acute
French Leucémie non lymphoblastique aiguë, Leucémie granuleuse aiguë, LMA, Leucémie granulocytaire aiguë, Leucémie aiguë myéloïde SAI, Leucémie myéloïde aiguë SAI, Leucémie aiguë myélocytaire, Leucémie myéloïde aiguë, Leucémie myélogène aigüe, Leucémie myélogène aiguë, LAM, Leucémie aiguë non lymphoblastique, Leucémie myéloblastique aigüe, Leucémie aigüe non lymphoblastique, Leucémie myéloblastique aiguë, Leucémie aiguë myéloblastique, Leucémie aiguë myéloïde, Leucémie aigüe myéloblastique, Leucémie myéloïde aigüe, Leucémie aigüe myéloïde, Leucémies myéloïdes aiguës, LANL
German akute granulozytische Leukaemie, AML, akute myeloische Leukaemie NNB, nicht-lymphoblastische Leukaemie akut, akute myelozytische Leukaemie, myeloische Leukaemie, akut, akute Myeloblastenleukaemie, Myeloblastenleukaemie akut, akute myeloblastische Leukaemie, Leukämie, myeloische, akute, Leukämie, myelogene, akute, Leukämie, myelozytäre, akute, Leukämie, nichtlymphatische, akute, Leukämie, myeloblastische, akute, Akute myeloische Leukaemie, Leukaemien akut myeloid, akute myeloische Leukaemie, ANLL, Leukämie, nichtlymphoblastische, akute, Nichtlymphoblastische Leukämie, akute, Nichtlymphozytäre Leukämie, akute
Portuguese Leucemia granulocítica aguda, Leucemia mieloblástica aguda, Leucemia mielóide aguda NE, Leucemia mielocítica aguda, Leucemia não linfoblástica aguda, Leucemia Mielógena Aguda, Leucemia Mieloide Aguda, Leucemia Aguda não Linfocítica, Leucemia Aguda Mieloide, Leucemia não Linfocítica Aguda, Leucemia mielóide aguda, Leucemias mielóides agudas
Japanese 急性顆粒球性白血病, 急性骨髄性白血病NOS, AML, キュウセイコツズイセイハッケツビョウ, キュウセイカリュウキュウセイハッケツビョウ, キュウセイコツズイガキュウセイハッケツビョウ, キュウセイコツズイセイハッケツビョウNOS, AML, キュウセイヒリンパガキュウセイハッケツビョウ, 骨髄性白血病-急性, 急性M2骨髄性白血病, 白血病-急性骨髄球性, M2急性骨髄性白血病, 白血病-急性骨髄芽球性, 急性骨髄白血病, 急性骨髄性白血病, 骨髄芽球性白血病, 骨髄芽球性白血病-急性, 急性骨髄性白血病-M2, 骨髄性白血病-急性-M1, 骨髄性白血病-急性-M2, 急性骨髄芽球性白血病, 白血病-急性M2骨髄性, 白血病-骨髄性-急性, 急性骨髄性白血病-M1, 白血病-骨髄芽球性-急性, 白血病-骨髄性-急性-M1, 白血病-急性骨髄性M1, 白血病-急性骨髄性M2, 白血病-骨髄芽球性, 急性M1骨髄性白血病, 白血病-骨髄性-急性-M2, 急性骨髄球性白血病, 白血病-急性M1骨髄性, 白血病-急性非リンパ性, 白血病-急性骨髄性, M1急性骨髄性白血病, 急性非リンパ性白血病, 急性非リンパ芽球性白血病, 白血病-非リンパ性-急性, 白血病-急性非リンパ芽球性, 白血病-非リンパ芽球性-急性, 非リンパ性白血病-急性, 非リンパ芽球性白血病-急性
Finnish Akuutti myeloidi leukemia
Swedish Leukemia, myeloisk, akut
Czech Akutní myeloidní leukemie, Akutní myeloblastická leukemie, Akutní nelymfoblastická leukemie, Akutní myeloidní leukemie NOS, Akutní myelocytická leukemie, Akutní granulocytická leukemie, Leukemie akutní myeloidní, AML, akutní myelogenní leukémie, akutní myelocytární leukémie, leukémie nonlymfocytární akutní, akutní myeloidní leukemie M1, leukémie myeloidní akutní, akutní myeloidní leukemie M2, akutní myeloidní leukémie, akutní myeloidní leukemie
Korean 급성 골수성 백혈병
Croatian Not Translated[Leukemia, Myeloid, Acute]
Polish Ostra białaczka szpikowa, Białaczka mieloblastyczna ostra, Białaczka szpikowa ostra, Białaczka nielimfoblastyczna ostra, ANLL
Hungarian Heveny granulocytás leukaemia, Myeloid leukemia, acut, Nem-lymphoblastos acut leukaemia, Acut myeloid leukemia k.m.n., Leukémia myeloblastos heveny, Acut myeloid leukemia, Acut myeloid leukaemia, Acut myeloblastos leukaemia, Acut myelocytás leukaemia, Heveny myeloblastos fehérvérűség, Fehérvérűség myeloblastos heveny, Acut granulocytás leukemia, Acut nem-lymphoblastos leukemia, Leukemiák, acut myeloid, AML, Acut myelocytás leukemia
Norwegian Akutt myelogen leukemi