II. Medications: S-Phase Specific
- Dactinomycin (Actinomycin D, Cosmegen)
- Anthracyclines
III. Medications: G2 and M-Phase Specific
IV. Medications: Not Phase Specific
- Plicamycin (Mithramycin)
- Mitomycin (Mitomycin C, Mitocin-C, Mutamycin)
- Mitoxantrone (Novantrone)
Images: Related links to external sites (from Bing)
Related Studies
| Definition (NCI) | An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. |
| Definition (NCI_NCI-GLOSS) | A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines. |
| Definition (CSP) | organic compounds with a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| SnomedCT | 108787006, 372540003 |
| English | Anthracycline Antibiotics, Anthracyc. antibiot antineopl., Anthracycline Antineoplastic Antibiotic, anthracycline antibiotic, anthracycline, Anthracycline antibiotic antineoplastic, Anthracycline (product), Anthracycline (substance), Anthracycline, Anthracyclines, Chemotherapy, Cancer, Anthracyclines |
| Spanish | antraciclina (producto), antraciclina (sustancia), antraciclina |
Ontology: Antibiotics, Antineoplastic (C0003236)
| Definition (NCI_NCI-GLOSS) | A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. |
| Definition (NCI) | An antibiotic, or its derivative, that can kill or inhibit the growth of tumor cells. Antineoplastic antibiotics can interfere with the normal function of cellular nucleic acids and proteins. |
| Definition (MSH) | Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. |
| Definition (CSP) | chemical substances produced by microorganisms, or synthetic derivatives of these substances, inhibiting or preventing the proliferation of neoplasms. |
| Concepts | Antibiotic (T195) |
| MSH | D000903 |
| SnomedCT | 38181000, 372723005 |
| English | Antibiotics, Antineoplastic, Antineoplastic Antibiotics, ANTINEOPL ANTIBIOTICS, ANTIBIOTICS ANTINEOPL, ANTINEOPLASTIC ANTIBIOTICS, antitumor antibiotics, antitumor antibiotics (medication), [AN200] ANTINEOPLASTIC ANTIBIOTICS, Antineoplastic antibiotics, anticancer antibiotic, antineoplastic antibiotics, Antineoplastic antibiotic (product), Antineoplastic antibiotic (substance), Antineoplastic antibiotic, antineoplastic antibiotic, Antineoplastic antibiotic, NOS, Anticancer Antibiotics, Anticancer Antibiotic, Antineoplastic Antibiotic, Antitumor Antibiotics, Antitumor Antibiotic |
| French | Antibiotiques anticancéreux, Antibiotiques antinéoplasiques, Antinéoplasiques antibiotiques |
| Swedish | Antibiotika vid cancerterapi |
| Czech | antibiotika antitumorózní |
| Finnish | Antineoplastiset mikrobilääkkeet |
| Russian | ANTIBIOTIKI ANTRATSIKLINOVYE, ANTRATSIKLINOVYE ANTIBIOTIKI, TSITOTOKSICHESKIE ANTIBIOTIKI, ANTIBIOTIKI PROTIVOOPUKHOLEVYE, АНТИБИОТИКИ АНТРАЦИКЛИНОВЫЕ, АНТИБИОТИКИ ПРОТИВООПУХОЛЕВЫЕ, АНТРАЦИКЛИНОВЫЕ АНТИБИОТИКИ, ЦИТОТОКСИЧЕСКИЕ АНТИБИОТИКИ |
| Japanese | 制がん抗生物質, 抗腫瘍系抗生物質, 細胞毒性抗生物質, 制癌抗生物質, 抗新生物抗生物質, 抗腫瘍抗生物質, 抗生物質-抗腫瘍性, 抗癌性抗生物質, 抗癌抗生物質, 抗腫瘍性抗生物質 |
| Croatian | ANTIBIOTICI, ANTITUMORSKI |
| Polish | Antybiotyki cytostatyczne, Antybiotyki przeciwnowotworowe |
| Portuguese | Antibióticos Antitumorais, Antibióticos Antineoplásicos |
| Spanish | antibiótico antineoplásico (producto), antibiótico antineoplásico (sustancia), antibiótico antineoplásico, Antibióticos Antineoplásicos |
| German | Antibiotika, antineoplastische, Antineoplastische Antibiotika |
| Italian | Antibiotici antineoplastici |
Ontology: Anthracyclines (C0282564)
| Definition (MSH) | Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine. |
| Concepts | Organic Chemical (T109) |
| MSH | D018943 |
| English | Anthracyclines, Anthracyclines [Chemical/Ingredient], anthracyclines, anthracycline |
| Swedish | Antracykliner |
| Finnish | Antrasykliinit |
| Russian | ANTRATSIKLINY, АНТРАЦИКЛИНЫ |
| Croatian | Not Translated[Anthracyclines] |
| Polish | Antracykliny pochodne |
| Czech | antracykliny, anthracykliny, antracyklíny |
| French | Anthracyclines |
| German | Anthracycline |
| Italian | Antracicline |
| Portuguese | Antraciclinas |
| Spanish | Antraciclinas |
