II. Indications
- FDA Approved
- Off-Label
- Anal Cancer
- Bladder Cancer (superficial, intravesical instillation)
- Cervical Cancer
- Esophageal Cancer
- Vulvar Cancer
III. Mechanism
- See Antibiotic Chemotherapy
- Mitomycin C is a methylazirinopyrroloindoledione Antineoplastic Antibiotic
- Isolated from the bacterium Streptomyces caespitosus
- Mitomycin C is more toxic to hypoxic cells
- Bioreduced Mitomycin C inhibits DNA synthesis (as well as RNA and Protein synthesis)
- Generates free radicals
- Alkylates DNA
- Induces DNA interstrand cross-links
IV. Medications
- Mitomycin Injection Solution: 5, 20 and 40 mg vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Adult Respiratory Distress Syndrome
- Alopecia
- Severe skin and soft tissue necrosis on extravasation
- Idarubicin is a strong Vesicant (causes Blistering)
- Hemolytic Uremic Syndrome
- Myelosuppression
- Nephrotoxicity
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
VIII. Resources
- Mitomycin Injection Powder for Solution (DailyMed)
- Mitomycin (StatPearls)
Images: Related links to external sites (from Bing)
Related Studies
Definition (NCI) | A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04) |
Definition (MSH) | An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis. |
Definition (CSP) | antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis. |
Definition (PDQ) | A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1820" NCI Thesaurus) |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D016685 |
SnomedCT | 387331000, 59240002 |
English | Mitomycin, Mitomycin C, Mitomycin-C, Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-, [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, mitomycin C, mitomycin-C, MMC, MITOMYCIN, Mitomycin [Chemical/Ingredient], mtc, mitomycin c, c mitomycin, mitomycin-c, mmc, mitoMYcin, MitoMYcin, mitomycin, (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, MITOMYCIN C, Mito-C, chemotherapeutics mitomycin, mitomycin (medication), Mitomycin (product), Mitomycin (substance), MITC, MTC, MITO-C, MITO, Mitomycin-X, Mitomycine C, MMC-Mitomycin-C |
Swedish | Mitomycin |
Czech | mitomycin, mitomycin C |
Finnish | Mitomysiini |
Russian | MITOMITSIN, MITOMITSIN C, МИТОМИЦИН C, МИТОМИЦИН |
Japanese | マイトマイシン, マイトマイシンC |
Italian | Mitomicina C, Mitomicina-C, Mitomicina |
Croatian | MITOMICIN |
Polish | Mitomycyna, Mitomycyna C |
Spanish | mitomicina (producto), mitomicina (sustancia), mitomicina-C, mitomicina, Mitomicina C, Mitomicina |
French | Mitomycine c, Mitomycine |
German | Mitomycin C, Mitomycin |
Portuguese | Mitomicina C, Mitomicina |