III. Mechanism

  1. See Antibiotic Chemotherapy
  2. Mitomycin C is a methylazirinopyrroloindoledione Antineoplastic Antibiotic
    1. Isolated from the bacterium Streptomyces caespitosus
  3. Mitomycin C is more toxic to hypoxic cells
  4. Bioreduced Mitomycin C inhibits DNA synthesis (as well as RNA and Protein synthesis)
    1. Generates free radicals
    2. Alkylates DNA
    3. Induces DNA interstrand cross-links

IV. Medications

  1. Mitomycin Injection Solution: 5, 20 and 40 mg vials

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Adult Respiratory Distress Syndrome
  2. Alopecia
  3. Severe skin and soft tissue necrosis on extravasation
    1. Idarubicin is a strong Vesicant (causes Blistering)
  4. Hemolytic Uremic Syndrome
  5. Myelosuppression
  6. Nephrotoxicity

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Renal Function Tests

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Ontology: Mitomycin (C0002475)

Definition (NCI) A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
Definition (MSH) An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Definition (CSP) antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis.
Definition (PDQ) A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1820" NCI Thesaurus)
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D016685
SnomedCT 387331000, 59240002
English Mitomycin, Mitomycin C, Mitomycin-C, Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-, [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, mitomycin C, mitomycin-C, MMC, MITOMYCIN, Mitomycin [Chemical/Ingredient], mtc, mitomycin c, c mitomycin, mitomycin-c, mmc, mitoMYcin, MitoMYcin, mitomycin, (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, MITOMYCIN C, Mito-C, chemotherapeutics mitomycin, mitomycin (medication), Mitomycin (product), Mitomycin (substance), MITC, MTC, MITO-C, MITO, Mitomycin-X, Mitomycine C, MMC-Mitomycin-C
Swedish Mitomycin
Czech mitomycin, mitomycin C
Finnish Mitomysiini
Russian MITOMITSIN, MITOMITSIN C, МИТОМИЦИН C, МИТОМИЦИН
Japanese マイトマイシン, マイトマイシンC
Italian Mitomicina C, Mitomicina-C, Mitomicina
Croatian MITOMICIN
Polish Mitomycyna, Mitomycyna C
Spanish mitomicina (producto), mitomicina (sustancia), mitomicina-C, mitomicina, Mitomicina C, Mitomicina
French Mitomycine c, Mitomycine
German Mitomycin C, Mitomycin
Portuguese Mitomicina C, Mitomicina