II. Indications

III. Mechanism

  1. CCR4 (Chemokine receptor 4)
    1. CCR4 is a cell surface receptor that binds Cytokines (CCL2, CCL4, CCL5, CCL17 and CCL22)
    2. CCR4 Receptors are most commonly expressed on T-Lymphocytes, Mast Cells, Dendritic Cells and Natural Killer Cells
    3. CCR4 binding by Cytokine triggers chemotaxis of inflammatory cells (e.g. Natural Killer Cells)
  2. CCR4 Monoclonal Antibody (e.g. Mogamulizumab)
    1. Humanized Monoclonal Antibody selectively binds CCR4 and blocks chemotaxis, T-Cell proliferation and Angiogenesis

IV. Medications

  1. Mogamulizumab-kpkc (Poteligeo) solution for injection

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Infusion Reaction
  2. Dermatitis
    1. Hold for moderate to severe dermatitis
  3. Graft Versus Host Disease
    1. Status-post transplant patients
  4. Other common adverse effects
    1. Diarrhea
    2. Myalgias

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters, unknown safety)
    1. Use reliable Contraception

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