II. Indications

III. Mechanism

  1. CCR4 (Chemokine receptor 4)
    1. CCR4 is a cell surface receptor that binds Cytokines (CCL2, CCL4, CCL5, CCL17 and CCL22)
    2. CCR4 Receptors are most commonly expressed on T-Lymphocytes, Mast Cells, Dendritic Cells and Natural Killer Cells
    3. CCR4 binding by Cytokine triggers chemotaxis of inflammatory cells (e.g. Natural Killer Cells)
  2. CCR4 Monoclonal Antibody (e.g. Mogamulizumab)
    1. Humanized Monoclonal Antibody selectively binds CCR4 and blocks chemotaxis, T-Cell proliferation and Angiogenesis

IV. Medications

  1. Mogamulizumab-kpkc (Poteligeo) solution for injection

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Infusion Reaction
  2. Dermatitis
    1. Hold for moderate to severe dermatitis
  3. Graft Versus Host Disease
    1. Status-post transplant patients
  4. Other common adverse effects
    1. Diarrhea
    2. Myalgias

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters, unknown safety)
    1. Use reliable Contraception

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Related Studies

Ontology: Receptors, CCR4 (C0539692)

Definition (MSH) CCR receptors with specificity for CHEMOKINE CCL17 and CHEMOKINE CCL22. They are expressed at high levels in T-LYMPHOCYTES; MAST CELLS; DENDRITIC CELLS; and NK CELLS.
Concepts Receptor (T192) , Amino Acid, Peptide, or Protein (T116)
MSH D054398
English Receptors, CCR4, Antigens, CD194, CC Chemokine Receptors 4, CCR4 Receptor, Receptor, CCR4, CD194 Antigen, CD 194 ANTIGENS, CC Chemokine Receptor 4, CC CHEMOKINE RECEPTOR 004, CCR4 Receptors, CD194 Antigens, CCR 004 RECEPTORS, RECEPTORS CCR 004, ANTIGENS CD 194, Antigen, CD194, Receptors, CCR4 [Chemical/Ingredient]
Portuguese Receptor 4 da Quimiocina CC, Antígenos CD194, Receptores CCR4
Spanish Receptor 4 de Quimiocina CC, Receptores CCR4, Antígenos CD194
Finnish CCR4-reseptorit
French Récepteurs C-C CKR-4, Récepteurs CKR4, Récepteurs aux chimiokines C-C de type 4, Récepteurs des chimiokines CC de type 4, Antigène CD194, Récepteurs CC-CKR-4, Récepteurs CCR4, Récepteurs aux chimiokines CC de type 4, Récepteurs CCR-4, Antigènes CD194, Récepteurs CC-R4, CD194
German CC-Chemokin-Rezeptoren 4, CD194-Antigene, Antigene, CD194-, Rezeptoren, CCR4-, CCR4-Rezeptoren
Italian Recettori CCR4
Russian RETSEPTORY CCR4, АНТИГЕНЫ CD194, РЕЦЕПТОРЫ CCR4, CC KHEMOKINA RETSEPTOR 4, CC ХЕМОКИНА РЕЦЕПТОР 4, ANTIGENY CD194
Japanese CCケモカイン受容体4, CCR4受容体, 受容体4-CCケモカイン, CD194抗原
Czech CC chemokinový receptor 4, receptory CCR4, antigeny CD194, CCR4 receptory
Swedish CCR4-receptorer
Polish Antygeny CD194, Receptory CCR4

Ontology: mogamulizumab (C2987603)

Definition (NCI) A humanized monoclonal antibody directed against C-C chemokine receptor 4 (CCR4) with potential anti-inflammatory and antineoplastic activities. Mogamulizumab selectively binds to and blocks the activity of CCR4, which may inhibit CCR4-mediated signal transduction pathways and, so, chemokine-mediated cellular migration and proliferation of T cells, and chemokine-mediated angiogenesis. In addition, this agent may induce antibody-dependent cell-mediated cytotoxicity (ADCC) against CCR4-positive T cells. CCR4, a G-coupled-protein receptor for C-C chemokines such MIP-1, RANTES, TARC and MCP-1, is expressed on the surfaces of some types of T cells, endothelial cells, and some types of neurons. CCR4, also known as CD194, may be overexpressed on adult T-cell lymphoma (ATL) and peripheral T-cell lymphoma (PTCL) cells.
Concepts Immunologic Factor (T129) , Pharmacologic Substance (T121)
MSH C549035
English Mogamulizumab, mogamulizumab, Immunoglobulin G1, Anti-(CC Chemokine Receptor CCR4) (Human-Mouse Monoclonal KW-0761 Heavy Chain), Disulfide With Human-Mouse Monoclonal KW-0761 Kappa-Chain, Dimer, MOGAMULIZUMAB