II. Pathophysiology
- White Blood Cells in Blood Product stimulate transfusion recipient Antibody binding reaction OR
- Proinflammatory Cytokines contained in Blood Product
III. Risk Factors
IV. Signs
- Fever or Temperature increase of 1.8 F (1 C) within 4 hours of transfusion
- Chills
- Rigors
- Hypertension
- Tachycardia
- Tachypnea
V. Precautions
- FNHTR is a diagnosis of exclusion
- Exclude more serious causes in differential diagnosis
VI. Differential Diagnosis
- Other causes of fever (e.g. Sepsis)
- Transfusion Hemolysis
VII. Management
- Symptomatic
- Antipyretics
- Prophylactic use does NOT prevent reaction
- However, consider prophylaxis when prior FNHTR reaction, as it may allow for transfusion completion
VIII. Prevention
- Leukocyte reduction (leukoreduction) of cellular Blood Products (e.g. Packed Red Blood Cells)
- Washing and volume reduction of Platelet Transfusion
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Related Studies
| Concepts | Pathologic Function (T046) |
| ICD9 | 780.66 |
| ICD10 | R50.84 |
| English | Febrile nonhaemolytic transfusion reaction, Febrile nonhemolytic transfusion reaction, Feb nonhemo transf react, FNHTR |
| Dutch | febriele niet-hemolytische transfusiereactie |
| French | Réaction non hémolytique fébrile à la transfusion |
| German | febrile nicht-haemolytische Transfusionsreaktion |
| Italian | Reazione febbrile non emolitica da trasfusione |
| Portuguese | Reacção transfusional não-hemolítica febril |
| Spanish | Reacción febril post-transfusional no hemolítica |
| Japanese | 発熱性非溶血性輸血反応, ﾊﾂﾈﾂｾｲﾋﾖｳｹﾂｾｲﾕｹﾂﾊﾝﾉｳ |
| Czech | Febrilní nehemolytická reakce na transfúzi |
| Hungarian | Lázas nem haemolyticus transzfúziós reakció |
