Definition (MSH)
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Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
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Definition (NCI)
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A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.
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Definition (NCI_NCI-GLOSS)
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A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
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Definition (CSP)
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precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent; used in the treatment of lymphomas, leukemias and other cancers, and as an immunosupressive agent to prevent transplant rejection; its side effect, alopecia, has been used for defleecing sheep; may also cause sterility, birth defects, mutations, and cancer.
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Definition (PDQ)
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A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39748&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39748&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C405" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organophosphorus Compound
(T115)
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MSH |
D003520
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SnomedCT |
74470007, 387420009 |
LNC |
LP70366-7, MTHU029970 |
English |
Cyclophosphamide, Cyclophosphane, cyclophosphamide, N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide, Ciclofosfamide, Zytoxan, Cyclophosphan, Cyclophosphanum, Mitoxan, Claphene, 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide, Cyclophospham, Cyclophosphamidum, Ciclofosfamida, Syklofosfamid, cyclophosphamide (medication), CYCLOPHOSPHAMIDE, Cyclophosphamide [Chemical/Ingredient], cyts, cyclophosphane, cyt, CPM - cyclophosphamide, CYT - cyclophosphamide, CTX - cyclophosphamide, Cytophosphane, (-)-Cyclophosphamide, CPM, CTX, CYT, Cyclophosphamide (product), Cyclophosphamide (substance) |
Swedish |
Cyklofosfamid
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Czech |
cyklofosfamid
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Finnish |
Syklofosfamidi
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Russian |
TSIKLOFOSFAMID, ЦИКЛОФОСФАМИД |
Japanese |
シクロフォスファミド, シクロホスファミド, サイクロフォスファミド |
Italian |
Ciclofosfano, Ciclofosfamide |
Croatian |
CIKLOFOSFAMID
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Polish |
Cyklofosfamid, Endoksan |
Spanish |
CFM, ciclofosfamida (producto), ciclofosfamida (sustancia), ciclofosfamida, Ciclofosfamida |
French |
Cyclophosphamide
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German |
Cyclophosphamid
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Portuguese |
Ciclofosfamida
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