II. Definitions
III. Pathophysiology
- Inciting event impairs Hair Follicle mitotic and metabolic activity during Anagen phase (active phase)
- Toxins result in damage to Hair Shaft and breakage
- Hair Loss occurs when the Hair Bulb is damaged
IV. Causes
- Systemic conditions
- Medications
- Chemotherapy (affects 65% of patients)
- Cyclophosphamide
- Nitrosureas
- Doxorubicin (Adriamycin)
- Endocrine
- Elements
- Bismuth
- Arsenic
- Gold
- Miscellaneous
- Chemotherapy (affects 65% of patients)
V. Symptoms
- Diffuse hairs loss onset days to within 2 weeks (peaks at 1-2 months) after offending agent (often Chemotherapy)
- Self-limited and hair regrows after Chemotherapy or other toxic agent is discontinued
VI. Signs
- Non-scarring Alopecia
VII. Management
- Wig until resolution
- Minoxidil may be effective during regrowth period
- Scalp and hair cooling has been shown effective in Chemotherapy induced Hair Loss
- However cooling may not be recommended, as it may reduce medication distribution to the scalp
- Nangia (2017) JAMA 317(6): 596-605 [PubMed]
VIII. Course
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Related Studies
| Concepts | Disease or Syndrome (T047) |
| ICD10 | L65.1 |
| SnomedCT | 201148009, 86160006 |
| German | Anageneffluvium |
| Korean | 성장기 탈모 |
| English | anagen effluvium (diagnosis), Anagen effluvium (finding), Anagen effluvium, Anagen effluvium (disorder), effluvium; anagen, anagen; effluvium |
| Dutch | anageen; effluvium, effluvium; anageen, Anageen effluvium |
| Spanish | efluvio anágeno (trastorno), efluvio anágeno, efluvium anágeno |
