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Definition (CHV)
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a kind of cancer treatment drug
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Definition (CHV)
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a kind of cancer treatment drug
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Definition (NCI_NCI-GLOSS)
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A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.
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Definition (NCI)
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An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
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Definition (MSH)
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Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
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Definition (CSP)
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antineoplastic antibiotic obtained from Streptomyces peucetius; a hydroxy derivative of daunorubicin.
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| Concepts |
Organic Chemical
(T109)
, Antibiotic
(T195)
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| MSH |
D004317
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| SnomedCT |
372817009, 68444001 |
| LNC |
LP18382-9, MTHU004184 |
| English |
Doxorubicin, 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-, (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione, 14-Hydroxydaunomycin, (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, Doxorubicin [Chemical/Ingredient], adr, DOXOrubicin, doxorubicin, DOXORUBICIN, Doxorubicin (product), Doxorubicin (substance), ADM, ADR, DOX, Hydroxyl Daunorubicin, Hydroxyldaunorubicin |
| Swedish |
Doxorubicin
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| Czech |
doxorubicin
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| Finnish |
Doksorubisiini
|
| Russian |
DOKSORUBITSIN, ADRIABLASTIN, ADRIAMITSIN, АДРИАБЛАСТИН, АДРИАМИЦИН, ДОКСОРУБИЦИН |
| Japanese |
塩酸ドキソルビシン, ドキソルビシン, アドリアシン, アドリアマイシン |
| Spanish |
doxorrubicina, doxorubicina, doxorrubicina (producto), doxorubicina (producto), doxorubicina (sustancia), Clorhidrato de Doxorrubicina, doxorrubicina (sustancia), Doxorrubicina |
| Croatian |
DOKSORUBICIN
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| Polish |
Doksorubicyna, Adriamycyna |
| Portuguese |
Cloridrato de Doxorrubicina, Doxorrubicina |
| French |
Doxorubicine
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| German |
Doxorubicin
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| Italian |
Doxorubicina
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