II. Background

  1. No longer available (off market in U.S.) due to hepatotoxicity
  2. Listed for historical reasons only

III. Mechanism

IV. Indications: Non-Valvular Atrial Fibrillation

  1. Warfarin intolerant
  2. Patients with high risk of Intracranial Hemorrhage

V. Efficacy

  1. Advantages
    1. As effective as Warfarin with INR 2-3
    2. Ximelagartan does not require monitoring
    3. Ximelagartan has fewer bleeding complications
  2. Disadvantages
    1. Expensive
    2. Myocardial Ischemia risk
    3. Risk of severe liver toxicity

VI. Dosing

  1. Studies used fixed dose of 36 mg bid

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