II. Indications

  1. Illicit use by athletes as ergonomic aid (banned)
  2. Anemia
    1. Chronic Renal Failure
      1. Indicated to maintain Hemoglobin 10-12 mg/dl
      2. Decreases cardiovascular morbidity and mortality
      3. Increases quality of life
    2. Cancer Chemotherapy
      1. Indicated to maintain Hemoglobin >10 g/dl
      2. Contraindicated if serum Erythropoietin >200 mU/ml
      3. Increases Hemoglobin 2 g/dl
      4. Decreases transfusion need
      5. Increases quality of life
      6. Does not improve survival or delay disease progress
        1. Henke (2003) Lancet 362:1255-60 [PubMed]
    3. Anemia secondary to HIV Management (e.g. Zidovudine)
      1. Contraindicated if serum Erythropoietin >500 mU/ml
      2. Increases quality of life (e.g. Energy)
      3. Prolongs AIDS survival
    4. Prophylaxis before elective surgery (non-cardiac)
      1. Indicated before surgery where transfusion is otherwise predicted
    5. Other possible indications (covered by Medicare)
      1. Myelodysplastic Syndrome
      2. Hepatitis C (during treatment)
      3. Inflammatory Bowel Disease
      4. Rheumatoid Arthritis
      5. Systemic Lupus Erythematosus

III. Adverse effects

  1. Hypertension (25% of Renal Failure patients)
    1. Hypertensive Encephalopathy
    2. Seizures
  2. Thrombotic events (e.g. Myocardial Infarction)
  3. May promote growth of certain Breast Cancers

IV. Disadvantages

  1. See adverse effects above
  2. Cost: $3000 for 8 week cancer course

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Related Studies

Cost: Medications

procrit (on 1/14/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PROCRIT 10,000 UNITS/ML VIAL $236.20 per ml
PROCRIT 20,000 UNITS/ML VIAL $470.35 per ml
PROCRIT 4,000 UNITS/ML VIAL $96.22 per ml
PROCRIT 40,000 UNITS/ML VIAL $943.60 per ml