II. Indications: As part of Combination Regimens

  1. Acute Myelogenous Leukemia (AML, adults)
  2. Acute Lymphocytic Leukemia (ALL, adults and children)

III. Mechanism

  1. See Antibiotic Chemotherapy
  2. Daunorubicin is an anthracycline Aminoglycoside antineoplastic
    1. Daunorubicin is isolated from the bacterium Streptomyces peucetius (or Streptomyces coeruleorubidus)
  3. Daunorubicin interacts with DNA via topoisomerase
    1. Similar clinical effects as with Doxorubicin (hydroxylated form of Daunorubicin)
    2. Inhibits DNA Replication and repair
    3. Inhibits RNA and Protein synthesis

IV. Medications

  1. Injection Solution: 5 mg/ml in 4 and 10 ml vials
  2. Combination Agents
    1. Daunorubicin AND Cytarabine Liposomal (Vyxeos)

V. Dosing

  1. See other references for disease specific dosing protocols
  2. Adjust dosing in renal Impairment and hepatic Impairment

VI. Adverse Effects

  1. Cardiotoxicity (esp. Children)
  2. Infusion Reaction
  3. Myelosuppression
  4. Urine Discoloration (transient red coloration)

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
    2. Daunorubicin crosses the placenta
  3. Monitoring
    1. Complete Blood Count
    2. Cardiac Function
    3. Renal Function tests
    4. Liver Function Tests

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Daunorubicin (C0011015)

Definition (NCI) An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
Definition (NCI_NCI-GLOSS) The active ingredient in a drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.
Definition (MSH) A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Definition (CSP) anthracycline antibiotic produced by Streptomyces coeruleorubidus or Streptomyces peucetius and used as an antineoplastic.
Concepts Organic Chemical (T109) , Antibiotic (T195)
MSH D003630
SnomedCT 35300007, 372715008
English Dauno Rubidomycine, Dauno-Rubidomycine, Daunomycin, Daunorubicin, Rubidomycin, Rubomycin, 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, DNM, Rubomycin C, DRB, Daunorrubicina, DNR, (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione, Leukaemomycin C, daunorubicin (medication), DAUNORUBICIN, Daunorubicin [Chemical/Ingredient], dnm, rubidomycin, drb, rubomycin, DAUNOrubicin, daunorubicin, RUBOMYCIN C, 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, L-lyxo-Hexopyranoside, 3beta-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,alpha-, DAUNOMYCIN, Daunorubicin (product), Daunorubicin (substance), daunomycin
Swedish Daunorubicin
Czech daunorubicin
Finnish Daunorubisiini
Russian DAUNORUBITSIN, RUBOMITSIN, DAUNOMITSIN, RUBIDOMITSIN, ДАУНОМИЦИН, ДАУНОРУБИЦИН, РУБИДОМИЦИН, РУБОМИЦИН
Japanese ルビドマイシン, ダウノルビシン, ダウノマイシン, ルボマイシン
Italian Rubidomicina, Daunomicina, Dauno-rubidomicina, Daunorubicina
Croatian Not Translated[Daunorubicin]
Spanish daunorubicina, daunorrubicina (producto), daunorubicina (producto), daunorrubicina, daunorubicina (sustancia), daunorrubicina (sustancia), Daunomicina, Daunorrubicina, Rubidomicina, Rubomicina
Polish Daunorubicyna, Rubidomycyna
French Daunorubicine
German Daunomycin, Daunorubicin, Rubidomycin, Rubomycin
Portuguese Daunomicina, Daunorrubicina, Rubidomicina, Rubomicina