II. Indications
III. Mechanism
- See Antimetabolite Chemotherapy
- Antineoplastic, PyrimidineNucleoside analog of cytidine
- By binding DNA at cytidine binding sites, Decitabine blocks DNA methyltransferase, and in turn DNA methylation
IV. Medications
- Decitabine IV Solution in 50 mg vials
V. Dosing
- See other references for disease specific dosing protocols
-
Myelodysplastic Syndrome
- Infuse 20 mg/m2 IV over 1 hour daily for 5 days, and repeated every 4 weeks
VI. Adverse Effects
- Myelosuppression
- Pulmonary Edema
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Men should also not father children while taking Decitabine, and for 2 months after
- Monitoring