II. Indications
III. Mechanism
- See Antimetabolite Chemotherapy
- Antineoplastic, PyrimidineNucleoside analog of cytidine
- By binding DNA at cytidine binding sites, Decitabine blocks DNA methyltransferase, and in turn DNA methylation
IV. Medications
- Decitabine IV Solution in 50 mg vials
V. Dosing
- See other references for disease specific dosing protocols
-
Myelodysplastic Syndrome
- Infuse 20 mg/m2 IV over 1 hour daily for 5 days, and repeated every 4 weeks
VI. Adverse Effects
- Myelosuppression
- Pulmonary Edema
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Men should also not father children while taking Decitabine, and for 2 months after
- Monitoring
VIII. Resources
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Related Studies
Definition (NCI_NCI-GLOSS) | A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite. |
Definition (NCI) | A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) |
Definition (PDQ) | A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39299&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39299&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C981" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
MSH | C014347 |
SnomedCT | 420517007, 420759005 |
English | 2'-deoxy-5-azacytidine, 5-azadeoxycytidine, 5-deoxyazacytidine, 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, 5-Aza-2-deoxycytidine, 5-Azadeoxycytidine, 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Aza-2'deoxycytidine, Decitabine, Decitabine (product), Decitabine (substance), 5 Aza 2 desoxycytidine, 5 Azadeoxycytidine, 5-aza-2'-deoxycytidine, Dezocitidine, 5-aza-dCyd, Deoxyazacytidine, 5-Aza-2'deoxycytidine/Decitabine, decitabine, Decitabine for Injection, DECITABINE, decitabine [Chemical/Ingredient], decitabine (medication), 5 aza 2 deoxycytidine, DAC |
Spanish | decitabina, decitabina (producto), decitabina (sustancia) |