II. Indications

III. Mechanism

  1. See Antimetabolite Chemotherapy
  2. Antineoplastic, PyrimidineNucleoside analog of cytidine
    1. By binding DNA at cytidine binding sites, Decitabine blocks DNA methyltransferase, and in turn DNA methylation

IV. Medications

  1. Decitabine IV Solution in 50 mg vials

V. Dosing

  1. See other references for disease specific dosing protocols
  2. Myelodysplastic Syndrome
    1. Infuse 20 mg/m2 IV over 1 hour daily for 5 days, and repeated every 4 weeks

VI. Adverse Effects

  1. Myelosuppression
  2. Pulmonary Edema

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
    2. Men should also not father children while taking Decitabine, and for 2 months after
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests

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Ontology: decitabine (C0049065)

Definition (NCI_NCI-GLOSS) A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite.
Definition (NCI) A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)
Definition (PDQ) A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39299&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39299&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C981" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C014347
SnomedCT 420517007, 420759005
English 2'-deoxy-5-azacytidine, 5-azadeoxycytidine, 5-deoxyazacytidine, 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, 5-Aza-2-deoxycytidine, 5-Azadeoxycytidine, 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Aza-2'deoxycytidine, Decitabine, Decitabine (product), Decitabine (substance), 5 Aza 2 desoxycytidine, 5 Azadeoxycytidine, 5-aza-2'-deoxycytidine, Dezocitidine, 5-aza-dCyd, Deoxyazacytidine, 5-Aza-2'deoxycytidine/Decitabine, decitabine, Decitabine for Injection, DECITABINE, decitabine [Chemical/Ingredient], decitabine (medication), 5 aza 2 deoxycytidine, DAC
Spanish decitabina, decitabina (producto), decitabina (sustancia)