II. Indications

III. Mechanism

  1. See Antimetabolite Chemotherapy
  2. Antineoplastic, PyrimidineNucleoside analog of cytidine
    1. By binding DNA at cytidine binding sites, Decitabine blocks DNA methyltransferase, and in turn DNA methylation

IV. Medications

  1. Decitabine IV Solution in 50 mg vials

V. Dosing

  1. See other references for disease specific dosing protocols
  2. Myelodysplastic Syndrome
    1. Infuse 20 mg/m2 IV over 1 hour daily for 5 days, and repeated every 4 weeks

VI. Adverse Effects

  1. Myelosuppression
  2. Pulmonary Edema

VII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
    2. Men should also not father children while taking Decitabine, and for 2 months after
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests

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