Trifluridine-Tipiracil

Aka: Trifluridine-Tipiracil, Trifluridine, Lonsurf

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II. Indications

  1. Colorectal Cancer (metastatic)
  2. Gastric or gastroesophageal junction adenocarcinoma (metastatic, refractory)

III. Mechanism

  1. Trifluridine
    1. Fluorinated thymidine analog with both antineoplastic and Antiviral activity
    2. As a thymidine analog, Trifluridine is incorporated into DNA
      1. Inhibits thymidylate synthase
      2. Inhibits DNA synthesis and Protein synthesis
  2. Tipiracil
    1. Thymidine phosphorylase inhibitor
    2. Thymidine is added to Trifluridine, to slow its metabolism, and potentiate its activity

IV. Medications

  1. Trifluridine/Tipiracil Tablets: 15 mg/6.14 mg and 20 mg/8.19 mg

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Pharmacokinetics

  1. Trifluridine is metabolized by Thymidine phosphorylase

VII. Adverse Effects

  1. Myelosuppression (severe)

VIII. Safety

  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count (CBC)
      1. Obtain prior to dosing and again on Day 15 of Chemotherapy cycle

IX. Resources

  1. Trifluridine-Tipiracil Tablets (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5beed22-d71d-4c0d-8dca-2c7317d65d85

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Related Studies

Cost: Medications

trifluridine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIFLURIDINE 1% EYE DROPS Generic $19.43 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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