Definition (NCI_NCI-GLOSS)
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A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.
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Definition (NCI)
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An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.
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Definition (MSH)
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A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
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Definition (CSP)
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pyrimidine analog that is an antineoplastic antimetabolite.
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Definition (PDQ)
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An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), a necessary constituent of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C505" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
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MSH |
D005472
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SnomedCT |
3127006, 387172005 |
LNC |
LP16149-4, MTHU016749, LA14338-0 |
English |
5 Fluorouracil, 5-Fluorouracil, Fluoruracil, 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-, 5-FU, 5FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, fluorouracil, 5fluorouracil, Fluoro Uracil, Fluouracil, 5Fluracil, 5-fluorouracil (medication), 5-fluorouracil, FLUOROURACIL, Fluorouracil [Chemical/Ingredient], 5 fu, 5-fu, 5 fluorouracil, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fu, Fluorouracil®, 5FU - Fluorouracil, Fluorouracil (product), Fluorouracil (substance), 5-Fluracil, FU, Fluorouracil |
Swedish |
Fluorouracil
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Czech |
fluorouracil
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Finnish |
Fluorourasiili
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Russian |
FTORURATSIL, ФТОРУРАЦИЛ |
Japanese |
フルオロウラシル, 5-フルオロウラシル |
Italian |
5-FU, 5FU, 5-Fluorouracile, Fluorouracile |
Polish |
Fluorouracyl
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Portuguese |
Fluorouracil, Fluoruracila |
Spanish |
5-fluorouracilo, fluorouracilo (producto), fluorouracilo (sustancia), fluorouracilo, Fluorouracilo |
French |
Fluorouracile
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German |
Fluoruracil
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