Definition (NCI_NCI-GLOSS)
|
A drug that treats infections caused by fungi.
|
Definition (NCI)
|
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
|
Definition (MSH)
|
A fluorinated cytosine analog that is used as an antifungal agent.
|
Definition (CSP)
|
fluorinated cytosine analog that is used as an antifungal agent.
|
Definition (PDQ)
|
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C501" NCI Thesaurus)
|
Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
|
MSH |
D005437
|
SnomedCT |
28506006, 387155003 |
LNC |
LP14376-5, MTHU027149 |
English |
5-Fluorocytosine, Flucytosine, 2(1H)-Pyrimidinone, 4-amino-5-fluoro-, 4-Amino-5-fluoro-2(1H)-pyrimidinone, flucytosine, 5FC, FLUOROCYTOSINE 05, fluorocytosine, flucytosine (medication), Flucytosine [Chemical/Ingredient], 5-fc, FLUCYTOSINE, 5-FC, Flucytosine (product), Flucytosine (substance) |
Swedish |
Flucytosin
|
Czech |
flucytosin, 5-fluorocytosin |
Finnish |
Flusytosiini
|
Russian |
5-FTORTSITOZIN, FLUTSITOZIN, 5-ФТОРЦИТОЗИН, ФЛУЦИТОЗИН |
Italian |
5-Fluorocitosina, Flucitosina |
German |
FLUORCYTOSIN 05, 5-Fluorcytosin, Flucytosin |
Polish |
Ancobon, 5-fluorocytozyna, Flucytozyna |
Japanese |
5-フルオロシトシン, 5-フルオロサイトシン, フルシトシン |
Portuguese |
5-Fluorocitosina, Flucitosina, 5-Fluorcitosina |
Spanish |
5-fluorcitosina (sustancia), 5-fluorcitosina, 5-fluorocitosina, flucitosina (producto), flucitosina (sustancia), flucitosina, 5-Fluorocitosina, Flucitosina |
French |
Flucytosine
|