Acute Nitrofurantoin Pulmonary Toxicity

Aka: Acute Nitrofurantoin Pulmonary Toxicity

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II. Epidemiology

  1. More common in younger patients

III. Symptoms

  1. Fever
  2. Cough
  3. Chest Pain
  4. Fever
  5. Rash (variably present)

IV. Labs

  1. Complete Blood Count
    1. Eosinophilia

V. Imaging: Chest XRay

  1. Diffuse Pulmonary Infiltrates

VI. Differential Diagnosis

  1. Idiopathic Pulmonary Fibrosis
    1. Occurs with Nitrofurantoin and GFR <30 ml/min

VII. Management

  1. Immediate Nitrofurantoin cessation (resolves on stopping Nitrofurantoin)
  2. Consider Corticosteroids

VIII. References

  1. Vahid (2006) Internet J Pulm Med 6(2): 1531-2984

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