II. Pharmacology
- Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
- Sulfonamide Allergy does NOT cross react with sulfur, sulfate, Sulfites (e.g. Morphine Sulfate, Clopidogrel bisulfate)
III. Preparations: Sulfonylarylamines (Sulfa agents)
-
General
- Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
-
Sulfa Antibiotics
- Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
- Sulfadiazine
- Sulfacetamide
- Sulfapyridine
- Sulfa Antiinflammatories
- Sulfasalazine (metabolized to sulfapyridine)
-
Protease Inhibitors (HIV Infection)
- Amprenavir
- Darunavir (Prezista)
- Fosamprenavir (Lexiva)
- Tipranavir
- Simeprevir (Olysio, for Hepatitis C Infection)
IV. Preparations: Non-Sulfonylarylamines
-
General
- Similar structure to Sulfonylarylamines , but Hypersensitivity cross-reactivity is uncommon
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
-
Diuretics
- All Thiazide Diuretics
- Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
- Carbonic Anhydrase Inhibitors (e.g. Acetazolamide)
- Anti-hyperglycemics (Diabetes Mellitus)
- Sulfonylureas (e.g. Glipizide)
-
Analgesics
- COX-2 Inhibitors (e.g. Celecoxib or Celebrex)
V. Preparations: Sulfonamide Moieties
-
General
- Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
- Neurologic agents
- Triptans (e.g. Sumatriptan or Imitrex)
- Topiramate (Topamax)
- Zonisamide (Zonagran)
- Miscellaneous agents
VI. References
- (2014) Presc Lett 21(2): 10-11
- (2022) Presc Lett 29(10): 55-6
- Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
- Giles (2019) Pharmacy 7(3):132 +PMID: 31514363 [PubMed]
- Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]