II. Pharmacology
- Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
- Sulfonamide Allergy does NOT cross react with sulfur, sulfate, Sulfites (e.g. Morphine Sulfate, Clopidogrel bisulfate)
III. Preparations: Sulfonylarylamines (Sulfa agents)
-
General
- Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
-
Sulfa Antibiotics
- Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
- Sulfadiazine
- Sulfacetamide
- Sulfapyridine
- Sulfa Antiinflammatories
- Sulfasalazine (metabolized to sulfapyridine)
-
Protease Inhibitors (HIV Infection)
- Amprenavir
- Darunavir (Prezista)
- Fosamprenavir (Lexiva)
- Tipranavir
- Simeprevir (Olysio, for Hepatitis C Infection)
IV. Preparations: Non-Sulfonylarylamines
-
General
- Similar structure to Sulfonylarylamines , but Hypersensitivity cross-reactivity is uncommon
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
-
Diuretics
- All Thiazide Diuretics
- Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
- Carbonic Anhydrase Inhibitors (e.g. Acetazolamide)
- Anti-hyperglycemics (Diabetes Mellitus)
- Sulfonylureas (e.g. Glipizide)
-
Analgesics
- COX-2 Inhibitors (e.g. Celecoxib or Celebrex)
V. Preparations: Sulfonamide Moieties
-
General
- Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
- Neurologic agents
- Triptans (e.g. Sumatriptan or Imitrex)
- Topiramate (Topamax)
- Zonisamide (Zonagran)
- Miscellaneous agents
VI. References
- (2014) Presc Lett 21(2): 10-11
- (2022) Presc Lett 29(10): 55-6
- Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
- Giles (2019) Pharmacy 7(3):132 +PMID: 31514363 [PubMed]
- Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]
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Related Studies
| Concepts | Disease or Syndrome (T047) |
| SnomedCT | 91939003 |
| English | SULFA ALLERGY, allergy sulfas, allergy to sulfa drugs, allergies drugs sulpha, allergies drug sulfa, allergy sulfa, sulfa drugs allergy, allergies sulfonamide, sulfa allergy, allergies sulfa, sulfonamide allergy, allergy drug sulfa, allergy drug sulpha, Sulfonamide allergy, Sulphonamide allergy, Allergy to sulfa drugs, Allergy to sulfonamides, Allergy to sulfonamides (disorder), Allergy to sulpha drugs, Allergy to sulphonamides |
| Dutch | allergie voor sulfonamide |
| French | Allergie aux sulfonamides |
| German | Sulfonamidallergie |
| Italian | Allergia alla sulfonamide |
| Portuguese | Alergia a sulfonamida |
| Spanish | Alergia a sulfonamidas, alergia a las sulfamidas, alergia a las sulfonamidas (trastorno), alergia a las sulfonamidas |
| Japanese | スルホンアミドアレルギー, ｽﾙﾎﾝｱﾐﾄﾞｱﾚﾙｷﾞｰ |
| Czech | Alergie na sulfonamidy |
| Hungarian | Szulfonamid allergia |
