II. Indications
III. Mechanism
IV. Dosing
- Adult (or child, weight >40 kg)
- Give 1 to 2 grams IV every 4 to 6 hours OR
- Give 500 mg IM every 4 to 6 hours
- Use 1 to 2 grams IV every 4 hours in Osteomyelitis
- Child (weight <40 kg)
- Mild to Moderate Infection
- Give 50 to 100 mg/kg/day IM or IV divided every 6 hours OR
- Give 25 mg mg/kg IM twice daily (has been used in low resource regions)
- Severe Infection
- Give 100 to 200 mg/kg/day IM or IV divided every 6 hours
- Mild to Moderate Infection
- Newborns (Weight >2 kg)
- Age <1 week
- Give 25 mg/kg IM or IV every 8 hours
- Age >1 week
- Give 25 to 35 mg/kg IM or IV every 6 hours
- Age <1 week
V. Adverse Effects
- Venous inflammation
-
Neutropenia
- Occurs with prolonged use
- Resolves on discontinuation of Nafcillin
VI. Drug Interactions
-
Warfarin
- Nafcillin may decrease INR
-
Cyclosporine
- Nafcillin may decrease Cyclosporine levels
VII. Safety
- Safe in Pregnancy
- Safe in Lactation
VIII. Resources
IX. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- Miller (2002) J Midwifery Womens Health 47(6):426-34 +PMID: 12484664 [PubMed]
- Bush (2016) Cold Spring Harb Perspect Med 6(8):a025247 +PMID: 27329032 [PubMed]
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Definition (NCI) | A semi-synthetic naphthalene and beta-lactam antibiotic with antibacterial activity. Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci. (NCI04) |
Definition (MSH) | A semi-synthetic antibiotic related to penicillin. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D009254 |
SnomedCT | 372898000, 91169009 |
LNC | LP14999-4, MTHU002302 |
English | Nafcillin, Naphthamidopenicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Nafcillin [Chemical/Ingredient], nafcillin (medication), nafcillin, NAFCILLIN, Nafcillin (product), Nafcillin (substance) |
Swedish | Nafcillin |
Czech | nafcilin |
Finnish | Nafsilliini |
Russian | NAFTAMIDOPENITSILLIN, NATRIIA NAFTSILLIN, NAFTSILLIN, НАТРИЯ НАФЦИЛЛИН, НАФТАМИДОПЕНИЦИЛЛИН, НАФЦИЛЛИН |
Japanese | ナフシリンナトリウム, ナフタミドペニシリン, ソジウムナフシリン, ナフシリン |
Polish | Nafcylina |
Spanish | nafcilina (producto), nafcilina (sustancia), nafcilina, Nafcilina, Naftamidopenicilina |
French | Nafcilline |
German | Nafcillin, Naphthamidopenicillin |
Italian | Nafcillina |
Portuguese | Nafcilina, Naftamidopenicilina |