II. Indications
- Regions with Plasmodium Vivax transmission
III. Contraindications
-
G6PD Deficiency
- Results in acute Hemolysis
IV. Directions
- May take with or without food
- Take with food to reduce gastric irritation
V. Adverse Effects
VI. Safety
- Pregnancy Category C
- Safe in children of all ages
VII. Dosing: Prophylaxis (adults)
- Standard
- Dose 52.6 mg daily starting 1-2 days before travel and continuing until 7 days after return
- Terminal prophylaxis (Following prolonged exposure to P. vivax or P. ovale)
- Dose 52.6 mg daily for 14 days on leaving endemic area
VIII. Dosing: Treatment
- Adults
- Dose: 30 mg base (52.6 mg salt) orally daily for 14 days or
- Dose: 45 mg base (78.9 mg salt) orally weekly for 8 weeks
- Children
- 0.3 mg base (0.5 mg/kg salt) orally daily for 14 days or
- 0.9 mg/kg base (1.5 mg/kg salt) orally once weekly for 8 weeks