IV. Dosing

  1. Directions
    1. Take on an empty Stomach
    2. Take more than 1 hour before or two hours after food
  2. Adult (or child weight >40 kg)
    1. Take 250 to 500 mg orally four times daily
  3. Child (age >1 month, weight <40 kg)
    1. Low dose (e.g. Upper Respiratory Infection, mild to moderate Skin Infections)
      1. Give 12.5 mg/kg/day orally divided four times daily
    2. Moderate dose (e.g. Pneumonia)
      1. Give 25 mg/kg/day orally divided four times daily
    3. High dose (Osteomyelitis)
      1. Give 50 to 100 mg/kg/day orally divided four times daily

V. Drug Interactions

  1. Warfarin
    1. Dicloxacillin may increase INR

VI. Safety

  1. Safe in Pregnancy
  2. Safe in Lactation

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

dicloxacillin (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DICLOXACILLIN 250 MG CAPSULE Generic $0.43 each
DICLOXACILLIN 500 MG CAPSULE Generic $1.01 each

Ontology: Dicloxacillin (C0012093)

Definition (NCI) A broad-spectrum, semi-synthetic, beta-lactam, penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Dicloxacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall. It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls. This leads to the inhibition of bacterial cell wall synthesis and eventually causes cell lysis.
Definition (MSH) One of the PENICILLINS which is resistant to PENICILLINASE.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D004009
SnomedCT 372873001, 8416000
LNC LP14990-3, MTHU002293
English Dichloroxacillin, Dicloxaciclin, Dicloxacillin, Dicloxacycline, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin, dicloxacillin, Dicloxacillin [Chemical/Ingredient], dicloxacillin (medication), DICLOXACILLIN, Dicloxacillin (product), Dicloxacillin (substance)
Swedish Dikloxacillin
Czech dikloxacilin
Finnish Dikloksasilliini
Russian DIKHLOROKSATSILLIN, DIKLOKSATSILLIN, ДИКЛОКСАЦИЛЛИН, ДИХЛОРОКСАЦИЛЛИН
Japanese ジクロキサシリン, ジクロロキサシリン, ジクロキサシリンナトリウム
Italian Dicloxacilina, Dicloxaciclina, Dicloxacillina
Polish Dikloksacylina
Spanish dicloxacilina (producto), dicloxacilina (sustancia), dicloxacilina, Dicloroxacilina, Dicloxacilina
French Dicloxacilline
German Dichloroxacillin, Dicloxacillin
Portuguese Dicloroxacilina, Dicloxacilina