IV. Dosing

  1. Adult (or child weight <40 kg)
    1. Give 1 to 2 grams IM or IV every 4 to 6 hours
    2. Use 1.5 to 2 grams IV every 4 hours in Osteomyelitis
  2. Child (weight <40 kg)
    1. Mild to Moderate Infection
      1. Give 100 to 150 mg/kg/day IM or IV divided every 6 hours
    2. Severe Infection
      1. Give 150 to 200 mg/kg/day IM or IV divided every 4 to 6 hours
  3. Newborns (Weight >2 kg)
    1. Age <1 week
      1. Give 25 to 50 mg/kg IV every 8 hours
    2. Age >1 week
      1. Give 25 to 50 mg/kg IM or IV every 6 hours

V. Adverse Effects

  1. Interstitial Nephritis
  2. Liver dysfunction
    1. Occurs with dose >12 g/day
    2. Monitor hepatic panel

VI. Safety

  1. Safe in Pregnancy
  2. Safe in Lactation

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Ontology: Oxacillin (C0029983)

Definition (NCI) A semisynthetic penicillinase-resistant and acid-stable penicillin with an antimicrobial activity. Oxacillin binds to penicillin-binding proteins in the bacterial cell wall, thereby blocking the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This leads to inhibition of cell growth and causes cell lysis.
Definition (MSH) An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D010068
SnomedCT 372868007, 83201006, 85724000
LNC LP16206-2, MTHU008465
English Methylphenylisoxazolyl Penicillin, Oxacillin, Oxazocilline, Penicillin, Methylphenylisoxazolyl, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Oxacillin [Chemical/Ingredient], oxacillin (medication), oxacillin, OXACILLIN, Methylphenyl isoxazolyl penicillin, Oxacillin (product), Oxacillin (substance)
Swedish Oxacillin
Czech oxacilin
Finnish Oksasilliini
Russian OKSATSILLIN, NATRIIA OKSATSILLIN, OKSAZOTSILLIN, PENITSILLIN, METILFENILIZOKSAZOLIL, НАТРИЯ ОКСАЦИЛЛИН, ОКСАЗОЦИЛЛИН, ОКСАЦИЛЛИН, ПЕНИЦИЛЛИН, МЕТИЛФЕНИЛИЗОКСАЗОЛИЛ
Japanese オキサゾシリン, メチルフェニルイソキサゾリルペニシリン, オキサシリン, ペニシリン-メチルフェニルイソキサゾリル, ソジウムオキサシリン, オキサシリンナトリウム
Croatian Not Translated[Oxacillin]
Polish Oksacylina, Penicylina metylfenyloksazolowa
Spanish metilfenil isoxazolil penicilina, oxacilina (producto), oxacilina (sustancia), oxacilina, Metilfenilisoxazolil Penicilina, Oxacilina, Oxazocilina
French Oxacilline
German Oxacillin, Oxazocillin, Penicillin, Methylphenylisoxazolyl-
Italian Oxacillina
Portuguese Metilfenilisoxazolil Penicilina, Oxacilina, Oxazocilina