II. Mechanism

III. Adverse Effects

IV. Dosing

  1. Take with food to reduce gastrointestinal upset
  2. Adult: 400 mg orally four times daily
  3. Child: 30-50 mg/kg/day PO divided four times daily

V. Adverse Effects

VI. Drug Interactions

  1. Strong CYP3A4 Inhibitor
    1. Numerous Drug Interactions
    2. Serious interactions resulting in death have occurred
  2. Warfarin
    1. May increase INR

VII. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

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