Definition (NCI)
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The ethylsuccinate salt form of erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin ethylsuccinate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin ethylsuccinate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.
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Definition (MSH)
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A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
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Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
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MSH |
D015643
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SnomedCT |
12578001, 419088007 |
English |
Erythromycin Ethylsuccinate, Ethylsuccinate, Erythromycin, Erythromycin, 2'-(ethyl butanedioate), Ethyl Succinate, Eyrthromycin, Eyrthromycin Ethyl Succinate, Succinate, Eyrthromycin Ethyl, ERYTHROMYCIN ETHYLSUCCINATE, erythromycin ethylsuccinate, erythromycin ethylsuccinate (medication), Erythromycin Ethylsuccinate [Chemical/Ingredient], erythromycin es, Erythromycin ES, Erythromycin ethylsuccinate, Erythromycin ethylsuccinate (substance), Erythromycin ethyl succinate (product), Erythromycin ethyl succinate |
Spanish |
etilsuccinato de eritromicina (producto), etilsuccinato de eritromicina (sustancia), etilsuccinato de eritromicina, Etilsuccinato de Eritromicina |
Swedish |
Erytromycinetylsuccinat
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Czech |
erythromycin ethylsukcinát
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Finnish |
Erytromysiinietyylisuksinaatti
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Italian |
Etil succinato di eritromicina, Etilsuccinato di eritromicina |
Russian |
ERITROMITSINA ETILSUKTSINAT, MONOMITSIN, МОНОМИЦИН, ЭРИТРОМИЦИНА ЭТИЛСУКЦИНАТ |
Japanese |
エチルコハク酸エリスロマイシン, エチルこはく酸エリスロマイシン, モノマイシン, エブシン, エリスロ(Erythromycin) |
Polish |
Etylobursztynian erytromycyny, Onomycyna |
French |
Éthyl-succinate d'érythromycine, Éthylsuccinate d'érythromycine |
German |
Erythromycin-Ethylsuccinat
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Portuguese |
Etilsuccinato de Eritromicina
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