II. Mechanism

III. Adverse Effects

IV. Dosing

  1. Take with food to reduce gastrointestinal upset
  2. Adult: 400 mg orally four times daily
  3. Child: 30-50 mg/kg/day PO divided four times daily

V. Adverse Effects

VI. Drug Interactions

  1. Strong CYP3A4 Inhibitor
    1. Numerous Drug Interactions
    2. Serious interactions resulting in death have occurred
  2. Warfarin
    1. May increase INR

VII. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Erythromycin Ethylsuccinate (C0014810)

Definition (NCI) The ethylsuccinate salt form of erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin ethylsuccinate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin ethylsuccinate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.
Definition (MSH) A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D015643
SnomedCT 12578001, 419088007
English Erythromycin Ethylsuccinate, Ethylsuccinate, Erythromycin, Erythromycin, 2'-(ethyl butanedioate), Ethyl Succinate, Eyrthromycin, Eyrthromycin Ethyl Succinate, Succinate, Eyrthromycin Ethyl, ERYTHROMYCIN ETHYLSUCCINATE, erythromycin ethylsuccinate, erythromycin ethylsuccinate (medication), Erythromycin Ethylsuccinate [Chemical/Ingredient], erythromycin es, Erythromycin ES, Erythromycin ethylsuccinate, Erythromycin ethylsuccinate (substance), Erythromycin ethyl succinate (product), Erythromycin ethyl succinate
Spanish etilsuccinato de eritromicina (producto), etilsuccinato de eritromicina (sustancia), etilsuccinato de eritromicina, Etilsuccinato de Eritromicina
Swedish Erytromycinetylsuccinat
Czech erythromycin ethylsukcinát
Finnish Erytromysiinietyylisuksinaatti
Italian Etil succinato di eritromicina, Etilsuccinato di eritromicina
Russian ERITROMITSINA ETILSUKTSINAT, MONOMITSIN, МОНОМИЦИН, ЭРИТРОМИЦИНА ЭТИЛСУКЦИНАТ
Japanese エチルコハク酸エリスロマイシン, エチルこはく酸エリスロマイシン, モノマイシン, エブシン, エリスロ(Erythromycin)
Polish Etylobursztynian erytromycyny, Onomycyna
French Éthyl-succinate d'érythromycine, Éthylsuccinate d'érythromycine
German Erythromycin-Ethylsuccinat
Portuguese Etilsuccinato de Eritromicina