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Myasthenia gravis is disease that causes weakness in the muscles under your control. It happens because of a problem in communication between your nerves and muscles. Myasthenia gravis is an autoimmune disease. Your body's own immune system makes antibodies that block or change some of the nerve signals to your muscles. This makes your muscles weaker.
Common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. But it can also affect other muscles. The weakness gets worse with activity, and better with rest..
There are medicines to help improve nerve-to-muscle messages and make muscles stronger. With treatment, the muscle weakness often gets much better. Other drugs keep your body from making so many abnormal antibodies. There are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. Sometimes surgery to take out the thymus gland helps.
For some people, myasthenia gravis can go into remission and they do not need medicines. The remission can be temporary or permanent.
If you have myasthenia gravis, it is important to follow your treatment plan. If you do, you can expect your life to be normal or close to it.
NIH: National Institute of Neurological Disorders and Stroke
|Definition (NCI_NCI-GLOSS)||A disease in which antibodies made by a person's immune system prevent certain nerve-muscle interactions. It causes weakness in the arms and legs, vision problems, and drooping eyelids or head. It may also cause paralysis and problems with swallowing, talking, climbing stairs, lifting things, and getting up from a sitting position. The muscle weakness gets worse during activity, and improves after periods of rest.|
|Definition (NCI)||A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness. It is caused by the blockage of the acetylcholine receptors at the neuromuscular junction.|
|Definition (MSH)||A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)|
|Definition (CSP)||disease characterized by progressive weakness and exhaustibility of voluntary muscles without atrophy or sensory disturbance and caused by an autoimmune attack on acetylcholine receptors at the neuromuscular junction.|
|Concepts||Disease or Syndrome (T047)|
|ICD10||G70.0 , G70.00|
|SnomedCT||193208002, 155092009, 91637004|
|Dutch||myasthenia gravis paralytica, gravis; myasthenie, myasthenie; gravis, myasthenia gravis, Myasthenia gravis|
|French||Myasthénie grave pseudo-paralytique, Myasthénie grave, Myasthénie, Myasthénie auto-immune, Myasthénie autoimmune|
|German||Myasthenia gravis paralytica, Myasthenia gravis|
|Italian||Miastenia gravis paralitica, Miastenia gravis, Miastenia grave|
|Portuguese||Miastenia grave paralítica, Miastenia Grave, Miastenia grave, Miastenia Gravis|
|Spanish||Miastenia gravis paralítica, miastenia gravis, SAI, miastenia gravis, SAI (trastorno), enfermedad de Erb - Goldflam, miastenia grave, miastenia gravis (trastorno), miastenia gravis, Miastenia gravis, Miastenia Gravis|
|English||Myasthenia Gravis, MYASTHENIA GRAVIS, MG, myasthenia gravis (diagnosis), myasthenia gravis, Myasthenia gravis paralytica, Myasthenia gravis NOS, Myasthenia Gravis [Disease/Finding], myasthenia gravis (MG), myasthenia gravis disorder, Myasthenia gravis NOS (disorder), Erb-Goldflam disease, Myasthenia gravis, MG - Myasthenia gravis, Myasthenia gravis (disorder), Erb-Goldflam, Goldflam-Erb, gravis; myasthenia, myasthenia; gravis, Myasthenia gravis, NOS|
|Japanese||麻痺性重症筋無力症, ｼﾞｭｳｼｮｳｷﾝﾑﾘｮｸｼｮｳ, ﾏﾋｾｲｼﾞｭｳｼｮｳｷﾝﾑﾘｮｸｼｮｳ, 重症筋無力症, 筋無力症, 筋無力症-重症|
|Czech||myasthenia gravis, Myasthenia gravis, Myastenia gravis, myastenie gravis|
|Russian||MIASTENIIA GREVIS, MIASTENIIA TIAZHELAIA PSEVDOPARALITICHESKAIA, ERBA-GOL'DFLAMA BOLEZN', MIASTENIIA, MYASTHENIA GRAVIS, МИАСТЕНИЯ, МИАСТЕНИЯ ГРЭВИС, МИАСТЕНИЯ ТЯЖЕЛАЯ ПСЕВДОПАРАЛИТИЧЕСКАЯ, ЭРБА-ГОЛЬДФЛАМА БОЛЕЗНЬ|
|Polish||Nużliwość mięśni rzekomoporaźna, Miastenia|
|Hungarian||Myasthenia gravis paralytica, Myasthenia gravis|