II. Risk Factors: Impacts mobility and stair climbing after ICU admit
- Prolonged ICU Stay
- Poor baseline health status
- Longer duration of Mechanical Ventilation
III. Pathophysiology
- Similar pathophysiology to Critical Illness Polyneuropathy
- Muscular deconditioning due to prolonged immobilization
- Myosin to Actin ratio reduced
- Lean Body Mass drops 2% per day with prolonged immobilization
IV. Diagnosis
- Similar diagnostic criteria for Critical Illness Polyneuropathy
- Limb Weakness AND
- Unexplained difficult mechanical Ventilator Weaning
V. Diagnostics
- Distinguish from Critical Illness Polyneuropathy
- Distinguish from other Myopathy
- Muscle Biopsy
VI. Management
- Physical Rehabilitation
- Contrast with Critical Illness Polyneuropathy in which physical therapy has no evidence of benefit
- Graded Exercise program
- Early mobilization is key
VII. Course
- Complications associated with deconditioning can persist 12 months after ICU admission