II. Risk Factors: Impacts mobility and stair climbing after ICU admit

  1. Prolonged ICU Stay
  2. Poor baseline health status
  3. Longer duration of Mechanical Ventilation

III. Pathophysiology

  1. Similar pathophysiology to Critical Illness Polyneuropathy
  2. Muscular deconditioning due to prolonged immobilization
  3. Myosin to Actin ratio reduced
  4. Lean Body Mass drops 2% per day with prolonged immobilization

IV. Diagnosis

  1. Similar diagnostic criteria for Critical Illness Polyneuropathy
  2. Limb Weakness AND
  3. Unexplained difficult mechanical Ventilator Weaning

V. Diagnostics

  1. Distinguish from Critical Illness Polyneuropathy
    1. Electromyography
    2. Nerve Conduction Velocity Studies
  2. Distinguish from other Myopathy
    1. Muscle Biopsy

VI. Management

  1. Physical Rehabilitation
    1. Contrast with Critical Illness Polyneuropathy in which physical therapy has no evidence of benefit
  2. Graded Exercise program
    1. Early mobilization is key

VII. Course

  1. Complications associated with deconditioning can persist 12 months after ICU admission

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Related Studies

Ontology: Critical illness myopathy (C1135188)

Concepts Disease or Syndrome (T047)
ICD9 359.81
ICD10 G72.81
SnomedCT 443819006
English critical illness myopathy, critical illness myopathy (diagnosis), Critical illness myopthy, Critical illness myopathy, Critical illness myopathy (disorder), Myopathy of critical illness, critical illness myopathies, myopathy of critical illness, myopathy critical illness
Spanish miopatía en dolencia crítica (trastorno), miopatía en dolencia crítica, Miopatía del paciente crítico
Czech Myopatie kriticky nemocných
Dutch kritieke ziekte myopathie
French Myopathie de maladie critique
German Critical-Illness-Myopathie
Hungarian Myopathia kritikus betegségben
Italian Miopatia da malattia critica
Japanese 重症疾患ミオパチー, ジュウショウシッカンミオパチー
Portuguese Miopatia de doença crítica