II. Indications
- Multiple Sclerosis related ambulatory dysfunction
III. Contraindications
- Seizure Disorder
- Renal Dysfunction (increases Dalfampridine drug levels)
- Dalfampridine is contraindicated with GFR <50 ml/min
- Seizure risk increased for GFR 50 to 80 ml/min
IV. Mechanism
- Primarily a Potassium Channel Blocker
- Also blocks Calcium channels
- May improve ambulation in Multiple Sclerosis
V. Medications
- Dalfampridine XR 10 mg tablets
VI. Dosing
- Adults: Dalfampridine XR 10 mg orally twice daily
VII. Adverse Effects
-
Seizures
- Increased risk with renal dysfunction (GFR 50 to 80 ml/min)
VIII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
IX. Resources
- Dalfampridine XR (DailyMed)
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Related Studies
| dalfampridine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DALFAMPRIDINE ER 10 MG TABLET | Generic | $0.61 each |