II. Indications
- Multiple Sclerosis related ambulatory dysfunction
III. Contraindications
- Seizure Disorder
- Renal Dysfunction (increases Dalfampridine drug levels)
- Dalfampridine is contraindicated with GFR <50 ml/min
- Seizure risk increased for GFR 50 to 80 ml/min
IV. Mechanism
- Primarily a Potassium Channel Blocker
- Also blocks Calcium channels
- May improve ambulation in Multiple Sclerosis
V. Medications
- Dalfampridine XR 10 mg tablets
VI. Dosing
- Adults: Dalfampridine XR 10 mg orally twice daily
VII. Adverse Effects
-
Seizures
- Increased risk with renal dysfunction (GFR 50 to 80 ml/min)
VIII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
IX. Resources
- Dalfampridine XR (DailyMed)
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Related Studies
dalfampridine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DALFAMPRIDINE ER 10 MG TABLET | Generic | $0.61 each |
Ontology: dalfampridine (C0000477)
Definition (MSH) | One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to characterize channel subtypes. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D015761 |
SnomedCT | 80994002, 413355004 |
English | 4 Aminopyridine, 4-Aminopyridine, Pymadine, 4-Pyridinamine, FAMPRIDINE (4-AMINOPYRIDINE), AMINOPYRIDINE 04, FAMPRIDINE, DALFAMPRIDINE, 4-Aminopyridine [Chemical/Ingredient], 4 aminopyridine, 4-aminopyridine, 4-AP, dalfampridine, fampridine, Dalfampridine, 4-Aminopyridine (substance), Fampridine, 4-Aminopyridine (product) |
Swedish | 4-aminopyridin |
Czech | 4-aminopyridin |
Finnish | 4-aminopyridiini |
Russian | 4-AMINOPIRIDIN, 4-АМИНОПИРИДИН |
Japanese | 4-アミノピリジン, アビトロール, ファムプリジン, 4-ピリジンアミン |
German | AMINOPYRIDIN 04, 4-Aminopyridin |
French | 4-Amino-pyridine, 4-Aminopyridine |
Polish | 4-aminopirydyna |
Spanish | 4-aminopiridina (sustancia), 4-aminopiridina, 4-aminopiridina (producto), 4-Aminopiridina |
Italian | 4-Aminopiridina |
Portuguese | 4-Aminopiridina |