II. Indications

  1. Multiple Sclerosis related ambulatory dysfunction

III. Contraindications

  1. Seizure Disorder
  2. Renal Dysfunction (increases Dalfampridine drug levels)
    1. Dalfampridine is contraindicated with GFR <50 ml/min
    2. Seizure risk increased for GFR 50 to 80 ml/min

IV. Mechanism

  1. Primarily a Potassium Channel Blocker
  2. Also blocks Calcium channels
  3. May improve ambulation in Multiple Sclerosis

V. Medications

  1. Dalfampridine XR 10 mg tablets

VI. Dosing

  1. Adults: Dalfampridine XR 10 mg orally twice daily

VII. Adverse Effects

  1. Seizures
    1. Increased risk with renal dysfunction (GFR 50 to 80 ml/min)

VIII. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

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Related Studies

Cost: Medications

dalfampridine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DALFAMPRIDINE ER 10 MG TABLET Generic $0.61 each

Ontology: dalfampridine (C0000477)

Definition (MSH) One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a research tool and to characterize channel subtypes.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D015761
SnomedCT 80994002, 413355004
English 4 Aminopyridine, 4-Aminopyridine, Pymadine, 4-Pyridinamine, FAMPRIDINE (4-AMINOPYRIDINE), AMINOPYRIDINE 04, FAMPRIDINE, DALFAMPRIDINE, 4-Aminopyridine [Chemical/Ingredient], 4 aminopyridine, 4-aminopyridine, 4-AP, dalfampridine, fampridine, Dalfampridine, 4-Aminopyridine (substance), Fampridine, 4-Aminopyridine (product)
Swedish 4-aminopyridin
Czech 4-aminopyridin
Finnish 4-aminopyridiini
Russian 4-AMINOPIRIDIN, 4-АМИНОПИРИДИН
Japanese 4-アミノピリジン, アビトロール, ファムプリジン, 4-ピリジンアミン
German AMINOPYRIDIN 04, 4-Aminopyridin
French 4-Amino-pyridine, 4-Aminopyridine
Polish 4-aminopirydyna
Spanish 4-aminopiridina (sustancia), 4-aminopiridina, 4-aminopiridina (producto), 4-Aminopiridina
Italian 4-Aminopiridina
Portuguese 4-Aminopiridina