II. Epidemiology
- ICU Admission annual Incidence (U.S.): 5 Million/year
- Survival of ICU stay to discharge: 70%
III. Evaluation
- Evaluate for complications (see below) in ICU Survivors after discharge and periodic intervals
- Medication Reconciliation (pre and post ICU admission)
- Consider restarting chronic medications that were stopped and not yet restarted at ICU discharge
- Evaluate medications started during hospitalization and continued at time of discharge
- Are medications to be continued longterm (e.g. advanced or modified therapy for chronic conditions)?
- Are medications intended for short-term use wih fixed duration (e.g. antiplatelet agents, Antibiotics)?
- Do new medications require additional monitoring (e.g. Electrolytes, weights on Diuretics)?
- Are new medications appropriate for the patient (e.g. medications on STOPP or Beers List)
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Advance Care Planning
- Discuss Advance Directive, POLST, Medical Directive, Living Will and Do-Not-Resuscitate (DNR)
- Does the patient have a Durable Power of Attorney
IV. Complications: General
- See Corona Virus 19 for Covid19 related complications
- Anemia Following ICU Admission
- Metabolic Bone Disease Following ICU Admission
- Neuromuscular Effects
- Myopathy Following ICU Admission
- Critical Illness Polyneuropathy
- Approach
- Both conditions (Neuropathy, Myopathy) present with Muscle Weakness and difficult Ventilator Weaning
- Electromyography (EMG) and Nerve Conduction Velocity Study, as well as Muscle biopsy differentiate these two
- Both conditions are reduced by early mobilization in the ICU
- Myopathy Following ICU Admission improves with physical therapy and Exercises
- Polyneuropathy responds poorly to physical therapy, but typically improves as medical disorders improve
-
Malnutrition Following ICU Admission
- Evaluate pre and post ICU admission weight and Caloric Intake
- Reduced appetite is common (Dysgeusia, Dysphagia)
- Deconditioning and Decreased Mobility
- New post-ICU related functional limitations persist at one year in 20% of ICU survivors
- Assess functional capacity after discharge and at 2-3 months after ICU discharge (PT referral as needed)
- Encourage regular Exercise and self-guided physical rehabilitation or formal physical therapy
- Consider Myopathy Following ICU Admission, Critical Illness Polyneuropathy, as well as Fatigue Causes (see below)
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Fatigue Causes
- Anemia Following ICU Admission
- Malnutrition Following ICU Admission
- Insomnia
- Major Depression
- Muscle Atrophy, Deconditioning or Neuromuscular effects (see above)
- Medication adverse effects
-
Alopecia
- Consider Telogen Effluvium (most common after major illness)
- Consider lab evaluation (e.g. TSH, CBC, Ferritin, ANA)
-
Amenorrhea
- Consider Hypothalamic Amenorrhea (most common after Critical Illness)
- Consider lab evaluation (bHCG, as well as GnRH, LH, FSH, Estrogen)
-
Stridor
- Consider post-intubation tracheal stenosis
-
Dyspnea
- See Dyspnea Causes
- Consider exacerbation of condition that required ICU admission or other preexisting comorbidity
- Pulmonary Embolism
- Congestive Heart Failure
- Anemia
- Fatigue
- Deconditioning
- Neuromuscular disorder (see above)
V. Complications: Psychosocial
-
Cognitive Impairment
- Persistent Cognitive Impairment is present in up to 20% of ICU Survivors
- Risk Factors include Hypotension, Hypoxia, hyperthermia, Delirium and some medications (Vancomycin, Quinolones)
- Sakusic (2018) Crit Care Med 46(12): 1977-84 [PubMed]
-
Anxiety Disorder
- See Generalized Anxiety Disorder Scale (GAD-7)
- Mood Disorder is present in 12 to 43% of ICU survivors at discharge
-
Post-Traumatic Stress Disorder (PTSD)
- See Post-Traumatic Stress Disorder Screening Tool
- PTSD is present in 7-20% of ICU Survivors at one year
- PTSD is also present in 18-31% of close family members (esp. female gender, mental illness, ICU patient previously healthy)
- Reduced risk of PTSD with ICU diary review while recovering
-
Major Depression
- See Patient Health Questionaire 9 (PHQ-9)
- Present in up to 30% of ICU Survivors at one year (esp. with Fatigue, depressed appetite)
- PTSD is associated with Severe Major Depression
- Associated with increased mortality at 2 years after ICU discharge
-
Sexual Dysfunction
- Present in up to nearly half of ICU survivors
- Consider PTSD, Anxiety and Major Depression
-
Sleep Disorder (esp. Insomnia)
- Present in 10-61% of ICU survivors at 6 months after discharge
- Risk Factors include comorbid mental illness and ICU-related Opioid use
- Associated with decreased physical functioning and increased pain
- Insomnia Nonpharmacologic Management is preferred
VI. Resources
- ICU Statistics (Society of Critical Care Medicine)