II. Causes: Psychogenic and Lifestyle (80%)
- Recovery from surgery (Fatigue may persist 12 weeks even following minor surgery)
- Sleep disorder (e.g. Insomnia)
- Lifestyle
- Work problems or dissatisfaction
- Home finances and relationships
- Sedentary lifestyle and deconditioning
- Inadequate nutrition
- Inadequate rest or Overtraining
- Mood Disorder
- Eating Disorder
-
Substance Abuse or medications
- Illicit Drug abuse or Substance Use Disorder
- Alcohol Use Disorder
- Tobacco Abuse
- Caffeine
- Amphetamines
- Sedative-Hypnotics medications or Tranquilizers
III. Causes: Organic (20%)
- Cardiopulmonary
- Infectious
- Metabolic disorder
- Hematologic or Oncologic Disorder
- Anemia
- Lymphoma
- Leukemia
- Occult malignancy
- Heavy Metal Toxicity (e.g. Lead Poisoning, Iron Overload)
- Renal Disease
-
Liver Disease
- Acute Hepatitis
- Chronic hepatitis
- Cirrhosis
- Rheumatologic Disease
- Gastrointestinal disorder
- Gynecologic
- Endometriosis
- Pregnancy
- Premenstrual Syndrome
- Neurologic
- Miscellaneous
IV. References
- Lipken in Dornbrand (1992) Ambulatory Care, p. 5-8
- Goroll (2000) Primary Care Medicine, Lippincott, p. 41
- Latimer (2023) Am Fam Physician 108(1): 58-69 [PubMed]
- Rosenthal (2008) Am Fam Physician 78(10): 1173-9 [PubMed]
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Related Studies
| Definition (CCC) | Exhaustion that interferes with physical and mental activities |
| Definition (MEDLINEPLUS) |
Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your fatigue and recommend ways to relieve it. Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to fatigue. These include
One disorder that causes extreme fatigue is chronic fatigue syndrome (CFS). This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities. NIH: National Institute on Aging |
| Definition (NCI) | Overall tiredness and lack of energy.(NICHD) |
| Definition (NCI) | A question about whether an individual has or had a lack of energy. |
| Definition (NCI_NCI-GLOSS) | A condition marked by extreme tiredness and inability to function due lack of energy. Fatigue may be acute or chronic. |
| Definition (NCI_CTCAE) | A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. |
| Definition (NAN) | An overwhelming sustained sense of exhaustion and decreased capacity for physical and mental work at usual level |
| Definition (MSH) | The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. |
| Definition (CSP) | state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. |
| Concepts | Sign or Symptom (T184) |
| MSH | D005221 |
| ICD10 | R53.83 |
| SnomedCT | 206767001, 206771003, 158169005, 367392001, 302758002, 139126000, 84229001, 248274002 |
| LNC | MTHU013358, LA7542-9 |
| French | FATIGUE, Fatigue extrême, Perte d'énergie, Energie diminuée, Ereinté, Lassitude, Sensation de manque total d'énergie, EPUISEMENT, FAIBLESSE, LASSITUDE, Fatigue |
| English | FATIGUE EXTREME, TIREDNESS, WEARINESS, [D]Fatigue, [D]Tiredness, [D]Fatigue (context-dependent category), [D]Tiredness (context-dependent category), Extreme fatigue, Decreased energy, decreased energy, fatigue (diagnosis), fatigue, Feeling of total lack of energy, Fatigue extreme, Tired out, Fatigue NOS, Fatigue [Disease/Finding], rndx fatigue (diagnosis), rndx fatigue, lacking energy, fatigues, loss of energy, tired time, tiredness, fatigue extreme, extreme fatigue, weariness, fatigued, tatt, time tired, energy loss, fatiguing, tired all the time, Lacks Energy, [D]Fatigue (situation), [D]Tiredness (situation), Lacking in energy (finding), Tiredness (finding), I have a lack of energy, FATIGUE, Lack Energy, Energy decreased, Tiredness, Lack of energy, Loss of energy, Weariness, Fatigue (finding), Lack of energy (finding), Lacking in energy, Fatigue, Lack of Energy, lack of energy, Lack (of);energy |
| Portuguese | FADIGA, Fadiga extrema, Sensação de falta total de energia, Perda de energia, Exausto, Energia diminuída, CANSACO, ESGOTAMENTO, EXAUSTAO, Fadiga |
| Spanish | FATIGA, Abatimiento, Sensación de falta absoluta de energía, Pérdida de energía, Fatiga extrema, Cansado, Cansancio, Falta de energía, [D]cansancio (categoría dependiente del contexto), [D]fatiga (categoría dependiente del contexto), ABATIMIENTO, CANSANCIO, FATIGA EXTREMA, [D]cansancio (situación), [D]cansancio, [D]fatiga, faltante de energía, faltante de energía (hallazgo), [D]fatiga (situación), cansancio, falta de energía (hallazgo), falta de energía, fatiga (hallazgo), fatiga, pérdida de energía, Fatiga |
| German | ERMUEDUNG, Mangel an Energie, Muedigkeit extrem, Ueberdruss, Energie abgenommen, abgeschlafft, Gefuehl voelligen Energiemangels, Muedigkeit, ABGESCHLAGENHEIT, MUEDIGKEIT STARK, MUEDIGKEIT, Ermuedung, Ermüdung, Müdigkeit |
| Italian | Affaticamento, Affaticamento estremo, Esaurito, Sensazione di totale mancanza di energia, Perdita di energia, Energia ridotta, Stanchezza |
| Dutch | vermoeid, moeheid, uitzonderlijk moe, verlies van energie, gevoel van energieloosheid, energie afgenomen, vermoeidheid, Moeheid |
| Japanese | 活力低下, 活力喪失感, 活力喪失, 疲労困ぱい, 極度の疲労, 疲労, ﾋﾛｳｺﾝﾊﾟｲ, ｶﾂﾘｮｸﾃｲｶ, ｶﾂﾘｮｸｿｳｼﾂｶﾝ, ﾋﾛｳ, ｷｮｸﾄﾞﾉﾋﾛｳ, ｶﾂﾘｮｸｿｳｼﾂ |
| Swedish | Trötthet |
| Czech | únava, Utahanost, Extrémní únava, Utahaný, Ztráta energie, Úbytek energie, Únava, Vyčerpanost, Pocit celkového nedostatku energie |
| Finnish | Väsymys |
| Russian | UTOMLENIE, USTALOST', УСТАЛОСТЬ, УТОМЛЕНИЕ |
| Croatian | UMOR |
| Polish | Znużenie, Zmęczenie |
| Hungarian | Kimerültség, Defatigatio, Kifáradt, Teljes energiahiány érzete, Energia elvesztése, Fáradtság, Kimerültség, extrém, Csökkent energia |
| Norwegian | Tretthet, Utmattelse, Trøtthet, Fatigue |
