II. Findings
- Synovitis (hallmark finding in Connective Tissue Disorders)
III. Causes: Connective Tissue Disorders
- Amyloidosis
- Behcet's Syndrome
- Polymyalgia Rheumatica
- Sjogren's Syndrome
- Systemic Sclerosis
- CREST Syndrome
- Granulomatosis with Polyangiitis (previously known as Wegener's Granulomatosis)
- Spondyloarthropathy
- Lupus
- Myositis
IV. Labs: Screening Indications
- Precautions
- Connective Tissue Disorder labs are nonspecific
- Obtain labs only if a reasonable suspicion for underlying condition
-
Antinuclear Antibody test
- Mixed Connective Tissue Disease
- Confirm with anticardiolipin ab, anti-CCP, Anti-Jo1, Anti-RNP, Anti-Scl-70, Rheumatoid Factor
- Dermatomyositis or Polymyositis
- Sjogren Syndrome
- Systemic Lupus Erythematosus
- Confirm with anticardiolipin ab, Anti-dsDNA, Anti-SSA, Anti-SSB, Anti-Sm, Anti-U1 snRNP, Lupus Anticoagulant
- Mixed Connective Tissue Disease
- Antineutrophil Cytoplasmic Antibody (ANCA)
-
Rheumatoid Factor
-
Rheumatoid Arthritis
- Confirm with Anticyclic Citrullinated Peptide Antibody (anti-CCP)
-
Rheumatoid Arthritis
- Creatinine Phosphokinase (CPK)
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Related Studies
| Definition (CHV) | a disease of the tissue that support body structures |
| Definition (CHV) | a disease of the tissue that support body structures |
| Definition (CHV) | a disease of the tissue that support body structures |
| Definition (CHV) | a disease of the tissue that support body structures |
| Definition (MSHCZE) | Soubor poruch pojivové tkáně nejrůznější povahy, některé jsou dědičné, jiné získané, spočívají v abnormální struktuře nebo funkčnosti pojivové tkáně, a to jedné její součásti nebo jejich většího množství, jako např. kolagen, elastin nebo mukopolysacharidy. |
| Definition (MEDLINEPLUS) |
Connective tissue is the material inside your body that supports many of its parts. It is the "cellular glue" that gives your tissues their shape and helps keep them strong. It also helps some of your tissues do their work. Cartilage and fat are examples of connective tissue. There are over 200 disorders that impact connective tissue. Some, like cellulitis, are the result of an infection. Injuries can cause connective tissue disorders, such as scars. Others, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta, are genetic. Still others, like scleroderma, have no known cause. Each disorder has its own symptoms and needs different treatment. |
| Definition (NCI) | A congenital or acquired disorder characterized by abnormalities in one or more of the elements of the connective tissues. |
| Definition (MSH) | A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides. |
| Definition (CSP) | deviation from or interruption of the normal structure or function of the connective tissue. |
| Definition (CSP) | determination of diseases of the tissues that support or bind other tissues based on symptoms, medical history, risk factors, and clinical tests. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D003240 |
| SnomedCT | 105969002, 201432001, 268126004, 268048008 |
| English | Disease, Connective Tissue, Diseases, Connective Tissue, connective tissue disorder, connective tissue disorder diagnosis, CONNECTIVE TISSUE DIS, Disease of connective tissues, disorders of connective tissue, disorders of connective tissue (diagnosis), Connective tissue disorder NOS, Connective tissue disorders, Connective Tissue Diseases [Disease/Finding], connective tissue disease, connective tissue disorders, Disease;connective tissue, connective tissue diseases, Connective Tissue Disorders, Connective tissue diseases, Other musculoskelet/connectiv, Connective tissue dis., Connective tissue disorders NEC, Connective tissues--Diseases, DISEASE, CONNECTIVE TISSUE, TISSUE DISEASE, CONNECTIVE, CONNECTIVE TISSUE DISEASE, Disorder of Connective Tissue, Connective tissue disorder, Connective tissue disease, Connective Tissue Diseases, Disease of connective tissues (disorder), Disorder of connective tissue (disorder), Disorder of connective tissue, Connective Tissue Disease, Connective Tissue Disorder |
| Italian | Disturbi del tessuto connettivo, Malattia del tessuto connettivo, Malattia del tessuto connettivo NAS, Disturbi del tessuto connettivo NCA, Malattie del tessuto connettivo |
| Dutch | bindweefselaandoening NAO, bindweefselaandoeningen NEG, bindweefselaandoeningen, bindweefselaandoening, Bindweefselziekte, Bindweefselziekten, Ziekte, bindweefsel-, Ziekten, bindweefsel- |
| French | Connectivité SAI, Affections du tissu conjonctif NCA, Connectivite, Anomalies du tissu conjonctif ou connectivites, Maladies du tissu conjonctif |
| German | Erkrankung des Bindegewebes NNB, Erkrankungen des Bindegewebes ANE, Bindegewebserkrankung, Erkrankungen des Bindegewebes, Bindegewebskrankheiten |
| Portuguese | Afecção do tecido conjuntivo NE, Afecções do tecido conjuntivo NC, Afecção do tecido conjuntivo, Afecções do tecido conjuntivo, Doenças do Tecido Conjuntivo |
| Spanish | Trastorno del tejido conjuntivo NEOM, enfermedad del tejido conectivo (trastorno), Trastornos del tejido conjuntivo NCOC, enfermedad del tejido conjuntivo, Trastornos del tejido conjuntivo, Trastorno del tejido conjuntivo, trastorno del tejido conectivo (trastorno), trastorno del tejido conectivo, enfermedad del tejido conectivo, Enfermedades del Tejido Conjuntivo |
| Japanese | 結合組織障害, 結合組織障害ＮＯＳ, ｹﾂｺﾞｳｿｼｷｼｮｳｶﾞｲNOS, ｹﾂｺﾞｳｿｼｷｼｮｳｶﾞｲ, 結合組織疾患, 膠原病, 結合織疾患, ｹﾂｺﾞｳｿｼｷｼｮｳｶﾞｲNEC, 結合組織障害ＮＥＣ, 結合組織病, 結合織病 |
| Swedish | Bindvävssjukdomar |
| Finnish | Sidekudossairaudet |
| Russian | SOEDINITEL'NOI TKANI BOLEZNI, SOEDINITEL'NOI TKANI DISPLAZIIA, СОЕДИНИТЕЛЬНОЙ ТКАНИ ДИСПЛАЗИЯ, СОЕДИНИТЕЛЬНОЙ ТКАНИ БОЛЕЗНИ |
| Czech | Porucha pojivové tkáně NOS, Porucha pojivové tkáně, Poruchy pojivové tkáně, pojivová tkáň - nemoci, nemoci pojiva, onemocnění pojivové tkáně, Poruchy pojivové tkáně NEC |
| Croatian | VEZIVNO TKIVO, BOLESTI |
| Latvian | Not Translated[Connective Tissue Diseases] |
| Polish | Choroby tkanki łącznej |
| Hungarian | Kötőszövet betegségek, Kötőszöveti betegség, Kötőszövet betegség k.m.n., Kötőszöveti betegségek m.n.o. |
| Norwegian | Bindevevssykdommer |
