II. Findings

  1. Synovitis (hallmark finding in Connective Tissue Disorders)

IV. Labs: Screening Indications

  1. Precautions
    1. Connective Tissue Disorder labs are nonspecific
    2. Obtain labs only if a reasonable suspicion for underlying condition
  2. Antinuclear Antibody test
    1. Mixed Connective Tissue Disease
      1. Confirm with anticardiolipin ab, anti-CCP, Anti-Jo1, Anti-RNP, Anti-Scl-70, Rheumatoid Factor
    2. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)
    3. Sjogren Syndrome
      1. Confirm with Sjogren antibodies (Anti-SSA, Anti-SSB)
    4. Systemic Lupus Erythematosus
      1. Confirm with anticardiolipin ab, Anti-dsDNA, Anti-SSA, Anti-SSB, Anti-Sm, Anti-U1 snRNP, Lupus Anticoagulant
  3. Antineutrophil Cytoplasmic Antibody (ANCA)
    1. Vasculitis
      1. Confirm with antiproteinase 3 Antibody, antimyeloperoxidase Antibody
  4. Rheumatoid Factor
    1. Rheumatoid Arthritis
      1. Confirm with Anticyclic Citrullinated Peptide Antibody (anti-CCP)
  5. Creatinine Phosphokinase (CPK)
    1. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)

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Related Studies

Ontology: Connective Tissue Diseases (C0009782)

Definition (CHV) a disease of the tissue that support body structures
Definition (CHV) a disease of the tissue that support body structures
Definition (CHV) a disease of the tissue that support body structures
Definition (CHV) a disease of the tissue that support body structures
Definition (MSHCZE) Soubor poruch pojivové tkáně nejrůznější povahy, některé jsou dědičné, jiné získané, spočívají v abnormální struktuře nebo funkčnosti pojivové tkáně, a to jedné její součásti nebo jejich většího množství, jako např. kolagen, elastin nebo mukopolysacharidy.
Definition (MEDLINEPLUS)

Connective tissue is the material inside your body that supports many of its parts. It is the "cellular glue" that gives your tissues their shape and helps keep them strong. It also helps some of your tissues do their work. Cartilage and fat are examples of connective tissue.

There are over 200 disorders that impact connective tissue. Some, like cellulitis, are the result of an infection. Injuries can cause connective tissue disorders, such as scars. Others, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta, are genetic. Still others, like scleroderma, have no known cause. Each disorder has its own symptoms and needs different treatment.

Definition (NCI) A congenital or acquired disorder characterized by abnormalities in one or more of the elements of the connective tissues.
Definition (MSH) A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
Definition (CSP) deviation from or interruption of the normal structure or function of the connective tissue.
Definition (CSP) determination of diseases of the tissues that support or bind other tissues based on symptoms, medical history, risk factors, and clinical tests.
Concepts Disease or Syndrome (T047)
MSH D003240
SnomedCT 105969002, 201432001, 268126004, 268048008
English Disease, Connective Tissue, Diseases, Connective Tissue, connective tissue disorder, connective tissue disorder diagnosis, CONNECTIVE TISSUE DIS, Disease of connective tissues, disorders of connective tissue, disorders of connective tissue (diagnosis), Connective tissue disorder NOS, Connective tissue disorders, Connective Tissue Diseases [Disease/Finding], connective tissue disease, connective tissue disorders, Disease;connective tissue, connective tissue diseases, Connective Tissue Disorders, Connective tissue diseases, Other musculoskelet/connectiv, Connective tissue dis., Connective tissue disorders NEC, Connective tissues--Diseases, DISEASE, CONNECTIVE TISSUE, TISSUE DISEASE, CONNECTIVE, CONNECTIVE TISSUE DISEASE, Disorder of Connective Tissue, Connective tissue disorder, Connective tissue disease, Connective Tissue Diseases, Disease of connective tissues (disorder), Disorder of connective tissue (disorder), Disorder of connective tissue, Connective Tissue Disease, Connective Tissue Disorder
Italian Disturbi del tessuto connettivo, Malattia del tessuto connettivo, Malattia del tessuto connettivo NAS, Disturbi del tessuto connettivo NCA, Malattie del tessuto connettivo
Dutch bindweefselaandoening NAO, bindweefselaandoeningen NEG, bindweefselaandoeningen, bindweefselaandoening, Bindweefselziekte, Bindweefselziekten, Ziekte, bindweefsel-, Ziekten, bindweefsel-
French Connectivité SAI, Affections du tissu conjonctif NCA, Connectivite, Anomalies du tissu conjonctif ou connectivites, Maladies du tissu conjonctif
German Erkrankung des Bindegewebes NNB, Erkrankungen des Bindegewebes ANE, Bindegewebserkrankung, Erkrankungen des Bindegewebes, Bindegewebskrankheiten
Portuguese Afecção do tecido conjuntivo NE, Afecções do tecido conjuntivo NC, Afecção do tecido conjuntivo, Afecções do tecido conjuntivo, Doenças do Tecido Conjuntivo
Spanish Trastorno del tejido conjuntivo NEOM, enfermedad del tejido conectivo (trastorno), Trastornos del tejido conjuntivo NCOC, enfermedad del tejido conjuntivo, Trastornos del tejido conjuntivo, Trastorno del tejido conjuntivo, trastorno del tejido conectivo (trastorno), trastorno del tejido conectivo, enfermedad del tejido conectivo, Enfermedades del Tejido Conjuntivo
Japanese 結合組織障害, 結合組織障害NOS, ケツゴウソシキショウガイNOS, ケツゴウソシキショウガイ, 結合組織疾患, 膠原病, 結合織疾患, ケツゴウソシキショウガイNEC, 結合組織障害NEC, 結合組織病, 結合織病
Swedish Bindvävssjukdomar
Finnish Sidekudossairaudet
Czech Porucha pojivové tkáně NOS, Porucha pojivové tkáně, Poruchy pojivové tkáně, pojivová tkáň - nemoci, nemoci pojiva, onemocnění pojivové tkáně, Poruchy pojivové tkáně NEC
Latvian Not Translated[Connective Tissue Diseases]
Polish Choroby tkanki łącznej
Hungarian Kötőszövet betegségek, Kötőszöveti betegség, Kötőszövet betegség k.m.n., Kötőszöveti betegségek m.n.o.
Norwegian Bindevevssykdommer