Connective Tissue Disorder

Aka: Connective Tissue Disorder, Connective Tissue Disease

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II. Findings

  1. Synovitis (hallmark finding in Connective Tissue Disorders)

III. Causes: Connective Tissue Disorders

  1. Amyloidosis
  2. Behcet's Syndrome
  3. Polymyalgia Rheumatica
  4. Sjogren's Syndrome
  5. Systemic Sclerosis
  6. CREST Syndrome
  7. Granulomatosis with Polyangiitis (previously known as Wegener's Granulomatosis)
  8. Spondyloarthropathy
  9. Lupus
    1. Antiphospholipid Antibody Syndrome
    2. Systemic Lupus Erythematosus
    3. Cutaneous Lupus Erythematosus
  10. Myositis
    1. Polymyositis
    2. Dermatomyositis

IV. Labs: Screening Indications

  1. Precautions
    1. Connective Tissue Disorder labs are nonspecific
    2. Obtain labs only if a reasonable suspicion for underlying condition
  2. Antinuclear Antibody test
    1. Mixed Connective Tissue Disease
      1. Confirm with anticardiolipin ab, anti-CCP, Anti-Jo1, Anti-RNP, Anti-Scl-70, Rheumatoid Factor
    2. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)
    3. Sjogren Syndrome
      1. Confirm with Sjogren antibodies (Anti-SSA, Anti-SSB)
    4. Systemic Lupus Erythematosus
      1. Confirm with anticardiolipin ab, Anti-dsDNA, Anti-SSA, Anti-SSB, Anti-Sm, Anti-U1 snRNP, Lupus Anticoagulant
  3. Antineutrophil Cytoplasmic Antibody (ANCA)
    1. Vasculitis
      1. Confirm with antiproteinase 3 Antibody, antimyeloperoxidase Antibody
  4. Rheumatoid Factor
    1. Rheumatoid Arthritis
      1. Confirm with Anticyclic Citrullinated Peptide Antibody (anti-CCP)
  5. Creatinine Phosphokinase (CPK)
    1. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)

V. References

  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]
  2. Stinton (2007) Autoimmun Rev (1):77-84 [PubMed]

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Related Studies

Related Topics in Connective Tissue Disorders

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