II. Pathophysiology

  1. Cross-over syndrome of Polymyositis or Dermatomyositis with other Connective Tissue Disorders

III. Signs

  1. Fever
  2. Nonerosive Arthritis
  3. Raynaud Phenomenon
  4. Interstitial Lung Disease
  5. Distal Fingertip fissures (mechanic's hands)

IV. Labs

  1. See Polymyositis and Dermatomyositis
  2. Screening
    1. Antinuclear Antibody
  3. Confirmation
    1. Myositis specific antibodies (of which Anti-Jo-1 Antibody is most sensitive) are only positive in 20% of cases

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