II. Definition
- Chronic, nonmalignant, noninfectious diseases
- Lower respiratory tract disease
- Distal lung parenchyma disease
- Alveolar wall inflammation and derangement
III. Causes (Mnemonic: DISCO)
- Drugs (See below)
- Idiopathic Pulmonary Fibrosis
- Sarcoidosis
- Collagen Vascular Disease
- Occupational Exposure
- Asbestos
- Fumes and gasses
IV. Causes: Non-Granulomatous Causes
- Occupational Exposure
- Medications
- Antibiotics (e.g. Nitrofurantoin and GFR<30 ml/min)
- Chemotherapeutics (e.g. Methotrexate)
- Radiation
- Aspiration Pneumonia
- Post ARDS changes
- Idiopathic Pulmonary Fibrosis
- Collagen Vascular Disease
- Goodpasture's Syndrome
- Eosinophilic Pneumonia
- Amyloidosis
- Graft Versus Host Disease (Bone Marrow Transplant)
V. Causes: Granulomatous Causes
- Hypersensitivity Pneumonitis (Organic dust)
- Inorganic dust (Beryllium silica)
- Sarcoidosis
- Langerhans Cell Granulomatosis
-
Granulomatous Vasculitis
- Granulomatosis with Polyangiitis (previously known as Wegener's Granulomatosis)
- Allergic Granulomatosis of Churg-Strauss
- Lymphomatoid Granulomatosis
- Bronchocentric Granulomatosis
VI. Epidemiology: Demographic Breakdown
- Age 20 to 40 years
- Sarcoidosis
- Collagen Vascular Disease
- Eosinophilic Granuloma or Pulmonary Histiocytosis X
- Lymphangioleiomyomatosis
- Age over 40 years
- Female Predominance
- Male Predominance
- Pneumoconiosis (Asbestosis)
- Tobacco exposure
VII. Symptoms
- Historical data
- Complete occupational and environmental exposures
- Complete medication history
- Exertional Dyspnea
- Chronic Dyspnea
- Fatigue
- Malaise
VIII. Signs
- Inspiratory crackles (rales) at posterior lung bases
- Pulmonary Hypertension
-
Fingernail
Clubbing
- Suggests Idiopathic Pulmonary Fibrosis
- May suggest Bronchogenic Carcinoma
IX. Labs
- ACE Level is non-specific and not useful
-
Erythrocyte Sedimentation Rate (ESR)
- Increased
-
Complete Blood Count (CBC)
- Polycythemia (rare)
- Arterial Blood Gas (ABG)
X. Diagnosis
-
Pulmonary Function Tests
- Restrictive pattern
- Reduced Total Lung Capacity
- DLCO decreased
- Bronchoalveolar Lavage
- Alveolar cells reflect type of inflammation
XI. Radiology
-
Chest XRay
- Lung parenchymal change (90%)
- Increased Interstitial Markings
- Non-resolving infiltrates
- Gallium Lung scanning
- Diffuse inflammation
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| Definition (MSH) | A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features. |
| Definition (MSHCZE) | Různorodá skupina plicních onemocnění, která ovlivňují plicní parenchym. Pro tuto skupinu nemocí je charakteristický prvotní zánět PLICNÍCH ALVEOL, který se rozšiřuje na intersticium a vede postupně k difúzní PLICNÍ FIBRÓZE. Intersticiální plicní nemoci jsou klasifikovány podle své etiologie (známých nebo neznámých příčin) a podle radiologicko patologických rysů. |
| Definition (MEDLINEPLUS) |
Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and scarring make it hard to get enough oxygen. The scarring is called pulmonary fibrosis. Breathing in dust or other particles in the air are responsible for some types of interstitial lung diseases. Specific types include
Other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. Some types of interstitial lung disease have no known cause. Treatment depends on the type of exposure and the stage of the disease. It may involve medicines, oxygen therapy, or a lung transplant in severe cases. |
| Definition (CSP) | heterogeneous group of noninfectious, nonmalignant disorders of the lower respiratory tract, affecting primarily the alveolar wall structures but also often involving the small airways and blood vessels of the lung parenchyma; may lead to respiratory insufficiency and death. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D017563 |
| ICD10 | J84.9 |
| SnomedCT | 233703007, 64667001 |
| English | Interstitial Lung Diseases, Lung Disease, Interstitial, INTERSTITIAL LUNG DISEASE, Interstitial Lung Disease, ILD - Intrstitial lung disease, Interstitial pulmonary disease, unspecified, INTERSTITIAL LUNG DIS, LUNG DIS INTERSTITIAL, ILD, Diffuse Parenchymal Lung Diseases, Lung Diseases, Interstitial [Disease/Finding], Lung Diseases, Interstitial, disease interstitial lung, interstitial disease lung, ild interstitial lung disease, lung interstitial disease, lung diseases interstitial, interstitial lung disease, interstitial lung diseases, interstitial lung disease (diagnosis), Interstitial pulmonary disease, Interstitial lung disease, ILD - Interstitial lung disease, Interstitial lung disease (disorder), lung; disease, interstitial |
| Italian | Malattia polmonare interstiziale, Malattie parenchimali diffuse del polmone, Malattie interstiziali del polmone |
| Spanish | Enfermedades Pulmonares Intersticiales, Enfermedades del Pulmón Intersticiales, PULMON, ENFERMEDAD INTERSTICIAL, Enfermedades Pulmonares Parenquimales Difusas, Neumopatías Intersticiales, enfermedad del intersticio pulmonar, enfermedad pulmonar intersticial (trastorno), enfermedad pulmonar intersticial, Enfermedad pulmonar intersticial |
| Swedish | Lungsjukdomar, interstitiella |
| Japanese | ｶﾝｼﾂｾｲﾊｲｼｯｶﾝ, 肺疾患-間質性, 間質性肺疾患 |
| Finnish | Interstitiaaliset keuhkosairaudet |
| Russian | PNEVMONIIA INTERSTITSIAL'NAIA, PNEVMONIT INTERSTITSIAL'NYI, PUL'MONIT INTERSTITSIAL'NYI, LEGKIKH BOLEZNI INTERSTITSIAL'NYE, INTERSTITSIAL'NYE BOLEZNI LEGKIKH, ИНТЕРСТИЦИАЛЬНЫЕ БОЛЕЗНИ ЛЕГКИХ, ЛЕГКИХ БОЛЕЗНИ ИНТЕРСТИЦИАЛЬНЫЕ, ПНЕВМОНИТ ИНТЕРСТИЦИАЛЬНЫЙ, ПНЕВМОНИЯ ИНТЕРСТИЦИАЛЬНАЯ, ПУЛЬМОНИТ ИНТЕРСТИЦИАЛЬНЫЙ |
| Portuguese | DOENCA INTERSTICIAL PULMONAR, Doenças Pulmonares Parenquimatosas Difusas, Doença pulmonar intersticial, Doenças Pulmonares Intersticiais |
| German | Interstitielle Lungenkrankheit, nicht naeher bezeichnet, LUNGENERKRANKUNG INTERSTITIELL, interstitielle Lungenerkrankung, Interstitielle Lungenkrankheiten, Lungenkrankheiten, interstitielle |
| French | PNEUMOPATHIE INTERSTITIELLE DIFFU, Maladies pulmonaires parenchymateuses diffuses, Pneumopathie interstitielle diffuse, Pneumopathies interstitielles, Maladies pulmonaires interstitielles |
| Czech | Intersticiální plicní onemocnění, plíce - nemoci intersticiální, intersticiální nemoci plic, intersticiální plicní procesy, intersticiální plicní nemoci |
| Korean | 상세불명의 사이질성 폐질환 |
| Croatian | PLUĆNE BOLESTI, INTERSTICIJSKE |
| Polish | Choroby płuc śródmiąższowe, Zapalenie płuc śródmiąższowe |
| Hungarian | Interstitialis tüdőbetegség |
| Norwegian | ILD, Interstitiell lungesykdom |
| Dutch | long; aandoening, interstitieel, Interstitiële longziekte, niet gespecificeerd, interstitiële longziekte, Interstitiële longziekte, Interstitiële longziekten, Longziekte, interstitiële, Longziekten, interstitiële, Ziekte, long-, interstitiële, Ziekten, long-, interstitiële |
