II. Mechanism
- Anti-Jo-1 Antibodies are directed against histidyl-Transfer RNA synthetase
- Anti-Jo-1 accounts for 80% of Myositis specific antibodies in Antisynthetase syndrome (subset of Polymyositis)
III. Causes: Negative
- Normal
IV. Causes: Positive (Percentage refers to Test Sensitivity)
- Polymyositis and Dermatomyositis (30%)
- Interstitial Lung Disease (Pulmonary fibrosis)
- Raynaud's Phenomenon
V. References
- Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
- Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
- Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
- Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]