II. Mechanism

  1. Anti-Jo-1 Antibodies are directed against histidyl-Transfer RNA synthetase
  2. Anti-Jo-1 accounts for 80% of Myositis specific antibodies in Antisynthetase syndrome (subset of Polymyositis)

III. Causes: Negative

  1. Normal

IV. Causes: Positive (Percentage refers to Test Sensitivity)

V. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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Related Studies

Ontology: Jo-1 antibody (C0064159)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH C046750
SnomedCT 45932003
English antinuclear antibody Jo 1, Histidyl t-RNA synthetase ab, antibodies jo 1, jo-1 antibody, Jo-1 antibody, Anti-Jo-1 Antibody, Anti Jo-1 antibody, Histidyl t-RNA synthetase antibody, Anti Jo-1 antibody (substance)
Spanish anticuerpo anti Jo - 1 (sustancia), anticuerpo anti Jo - 1

Ontology: Antibody to JO-1 measurement (C0201365)

Definition (NCI) The determination of the amount of Jo-1 antibody present in a sample.
Definition (NCI_CDISC) A measurement of the Jo-1 antibody in a biological specimen.
Concepts Laboratory Procedure (T059)
SnomedCT 33732007
English Jo-1 Antibody Measurement, Antibody to JO-1 measurement, JO1AB, Jo-1 Antibody, Antibody to JO-1 measurement (procedure)
Spanish mediciĆ³n de anticuerpos anti - JO - 1 (procedimiento), mediciĆ³n de anticuerpos anti - JO - 1