II. Mechanism

  1. Anti-Jo-1 Antibodies are directed against histidyl-Transfer RNA synthetase
  2. Anti-Jo-1 accounts for 80% of Myositis specific antibodies in Antisynthetase syndrome (subset of Polymyositis)

III. Causes: Negative

  1. Normal

IV. Causes: Positive (Percentage refers to Test Sensitivity)

V. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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