II. Indications
- Limited use in clinical practice
- May be indicated if Ankylosing Spondylitis strongly suspected
III. Labs: Methods of Testing
- Antibody binding to patient's cells
- Mixed Lymphocyte responses against specific targets
- Hybridization to DNA probes
IV. Efficacy
- Test Sensitivity for Spondyloarthropathy: 84%
- Test Specificity for Spondyloarthropathy: 96%
V. Causes: Positive HLA-B27 (with Incidence)
- Ankylosing Spondylitis: 95%
- Reiter's Syndrome (Reactive Arthritis): 80%
- Psoriatic Arthritis (Spondylitis with Psoriasis): 70%
- Enteropathic Arthritis (Spondylitis with Inflammatory Bowel Disease): 50%
- Incidence in general population without disease: 6-8%
VI. References
- Gregersen in Ruddy (2001) Kelly's Rheumatology, p. 101
- Lane (2002) Am Fam Physician 65(6):1073-80
- Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]