ANA Staining Pattern

Aka: ANA Staining Pattern, ANA Rim Pattern, ANA Peripheral Pattern, ANA Homogenous Pattern, ANA Speckled Pattern, ANA Nucleolar Pattern, ANA Diffuse Pattern, ANA Centromere Pattern, Serum ANA pattern, IgG Nuclear Staining Pattern, Nuclear Antibody Pattern Determination

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II. Causes: Rim Pattern (Peripheral Pattern)

  1. Systemic Lupus Erythematosus (Most Specific)

III. Causes: Homogenous Pattern (Diffuse Pattern)

  1. Systemic Lupus Erythematosus (Very specific)
  2. Further evaluation
    1. Anti-dsDNA
    2. Anti-ssDNA
    3. Anti-Smith

IV. Causes: Speckled Pattern

  1. Most common, least specific
  2. Disorders
    1. Systemic Lupus Erythematosus
    2. Mixed Connective Tissue Disease
    3. Scleroderma
    4. Sjogren's Syndrome
  3. Further evaluation
    1. Smith Antibody (Anti-Smith)
    2. Ribonucleoprotein Antibody (Anti-RNP)
    3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    4. Anti-La (Anti-SSB)

V. Causes: Nucleolar Pattern

  1. Disorders
    1. Scleroderma
    2. CREST syndrome
  2. Further evaluation
    1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    2. PM-1

VI. Causes: Centromere Pattern

  1. Seen in PSS with CREST syndrome

VII. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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Related Studies

Ontology: Nuclear Ab pattern.homogeneous (C0807128)

Concepts Laboratory or Test Result (T034)
LNC LP29189-5, MTHU009180
English Nuclear Ab pattern.homogeneous, Nuclear Antibody pattern.homogeneous
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Serum ANA pattern (C1271805)

Concepts Laboratory Procedure (T059)
SnomedCT 391317009, 389552001, 390284000
English Serum antinuclear antibody pattern, Serum antinuclear antibody pattern (procedure), Serum ANA pattern (procedure), Serum ANA pattern
Spanish patrón de AAN en suero, patrón de anticuerpos antinucleares en suero, patrón de anticuerpos antinucleares en suero (procedimiento)
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: IgG nuclear staining pattern (C1273296)

Concepts Laboratory Procedure (T059)
SnomedCT 393837007, 392882003, 395147009
English IgG nuclear staining pattern (procedure), Immunoglobulin G nuclear staining pattern, Immunoglobulin G nuclear staining pattern (procedure), IgG nuclear staining pattern
Spanish patrón de tinción de IgG nuclear (procedimiento), patrón de tinción de IgG nuclear
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Nuclear antibody pattern determination (C1294737)

Concepts Laboratory Procedure (T059)
SnomedCT 117919001
English Nuclear antibody pattern determination (procedure), Nuclear antibody pattern determination
Spanish determinación del patrón de los anticuerpos antinucleares (procedimiento), determinación del patrón de los anticuerpos antinucleares
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Nuclear antibody, centromere pattern assay (C1294742)

Concepts Laboratory Procedure (T059)
SnomedCT 117729000
English Nuclear antibody, centromere pattern assay (procedure), Nuclear antibody, centromere pattern assay
Spanish determinación del patrón centromérico de los anticuerpos antinucleares, anticuerpo antinuclear, determinación del patrón centromérico (procedimiento), anticuerpo antinuclear, determinación del patrón centromérico
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Speckled antinuclear antibody pattern (C2732788)

Concepts Finding (T033)
SnomedCT 444138006
English Speckled antinuclear antibody pattern, Speckled antinuclear antibody pattern (finding)
Spanish patrón de anticuerpo antinuclear moteado, patrón de anticuerpo antinuclear moteado (hallazgo)
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Peripheral antinuclear antibody pattern (C2733445)

Concepts Finding (T033)
SnomedCT 443767006
English Peripheral antinuclear antibody pattern, Rim antinuclear antibody pattern, Peripheral antinuclear antibody pattern (finding)
Spanish patrón periférico de anticuerpos antinucleares, patrón periférico de anticuerpos antinucleares (hallazgo)
Derived from the NIH UMLS (Unified Medical Language System)

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